Detection of DNA of Chlamydophila psittaci in subjects with psoriasis: a casual or a causal link?

Stinco, G., Fabris, M., Pasini, E., Pontarini, E., Patriarca, M. M., Piccirillo, F., De Vita, S. and Dolcetti, R. (2012) Detection of DNA of Chlamydophila psittaci in subjects with psoriasis: a casual or a causal link?. British Journal of Dermatology, 167 4: 926-928. doi:10.1111/j.1365-2133.2012.11043.x


Author Stinco, G.
Fabris, M.
Pasini, E.
Pontarini, E.
Patriarca, M. M.
Piccirillo, F.
De Vita, S.
Dolcetti, R.
Title Detection of DNA of Chlamydophila psittaci in subjects with psoriasis: a casual or a causal link?
Formatted title
Detection of DNA of Chlamydophila psittaci in subjects with psoriasis: a casual or a causal link?
Journal name British Journal of Dermatology   Check publisher's open access policy
ISSN 0007-0963
1365-2133
Publication date 2012-10-01
Year available 2012
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1111/j.1365-2133.2012.11043.x
Open Access Status Not yet assessed
Volume 167
Issue 4
Start page 926
End page 928
Total pages 3
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background: Recent evidence indicates that subclinical infection by Chlamydophila psittaci occurs in a significant percentage of patients with chronic inflammatory polyarthritis, including psoriatic arthritis.

Objective: To assess the prevalence of Chlamydiae infection in a large cohort of well-characterized patients with psoriasis.

Methods:
The presence of a subclinical C. psittaci infection was investigated in 64 patients with psoriasis, including 12 patients with psoriatic arthritis. Two hundred and twenty-five healthy controls were also investigated. The presence of infection was assessed in peripheral blood mononuclear cells using several polymerase chain reaction protocols, targeting different regions of the bacterial genome. The DNA of other species (Chlamydophila pneumoniae and Chlamydia trachomatis) was also investigated.

Results: Chlamydophila psittaci infection was observed in a significantly higher percentage of patients with psoriasis (11/64, 17%) compared with healthy controls (1/225, 0·4%) (odds ratio 46·49, 95% confidence interval 5·87-368·03; P < 0·0001). No differences in age, sex or disease duration were noticed between positive and negative patients, but the majority of the positive patients were on immunomodulatory treatments.

Conclusion: Chlamydophila psittaci may be an infectious trigger possibly involved in the pathogenesis of psoriasis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sat, 28 Nov 2015, 05:50:23 EST by System User on behalf of Learning and Research Services (UQ Library)