Hodgkins disease and human immunodeficiency virus infection: clinicopathological and virological features of 114 patients from the Italian cooperative group on AIDS and tumors

Tirelli, Umberto, Errante, Domenico, Dolcetti, Riccardo, Gloghini, Annunziata, Serraino, Diego, Vaccher, Emanuela, Franceschi, Silvia, Boiocchi, Maura and Carbone, Antonino (1995) Hodgkins disease and human immunodeficiency virus infection: clinicopathological and virological features of 114 patients from the Italian cooperative group on AIDS and tumors. Journal of Clinical Oncology, 13 7: 1758-1767. doi:10.1200/JCO.1995.13.7.1758

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Author Tirelli, Umberto
Errante, Domenico
Dolcetti, Riccardo
Gloghini, Annunziata
Serraino, Diego
Vaccher, Emanuela
Franceschi, Silvia
Boiocchi, Maura
Carbone, Antonino
Title Hodgkins disease and human immunodeficiency virus infection: clinicopathological and virological features of 114 patients from the Italian cooperative group on AIDS and tumors
Journal name Journal of Clinical Oncology   Check publisher's open access policy
ISSN 0732-183X
1527-7755
Publication date 1995-07-01
Year available 1995
Sub-type Article (original research)
DOI 10.1200/JCO.1995.13.7.1758
Open Access Status File (Publisher version)
Volume 13
Issue 7
Start page 1758
End page 1767
Total pages 10
Place of publication Alexandria, VA, United States
Publisher American Society of Clinical Oncology
Language eng
Formatted abstract
Purpose: To describe virologic, clinicopathologic, and therapeutic features of a large series of Italian patients with Hodgkin's disease (HD) and human immunodeficiency virus (HIV) infection.

Patients and Methods: From November 1986 to March 1994, 114 cases were observed. The relationship between Epstein-Barr virus (EBV) and HD was determined by an in situ hybridization technique, immunostaining for EBV-encoded latent membrane protein-1 (LMP-1) expression, and Southern blotting. Twenty-six patients were included in a prospective study evaluating the combination of chemotherapy (CT) with zidovudine.

Results: Combined approach on EBV study revealed that 14 (78%) of 18 patients were EBV-associated. An almost equivalent distribution of EBV subtypes was observed in EBV-carrying cases, indicating that in the HIV setting, type 2 EBV also may be pathogenetically involved in HD development. In comparing these 114 patients with our single-institutional series of 104 HIV-negative patients with HD, we observed at presentation a younger median age (29 v 38 years); a prevalence of males (90% v 56%); and a higher percentage of stage IV disease (52% v 15%), presence of B symptoms (77% v 35%), and extranodal disease (63% v 29%). The complete remission (CR) rate (58%) and median survival (13 months) of patients treated prospectively were similar to that of patients treated with standard CT regimens. The statistically significant favorable prognostic factors for survival being the following: achievement of CR, CD4+ count greater than 250/microL, and no prior diagnosis of AIDS at onset of HD.

Conclusion: Our virologic findings indicate that HIV-related HD is more closely associated with EBV than HD in the general population. The peculiar clinicopathologic findings, the role of some prognostic factors, and the possibility of cure of HIV-related HD have been demonstrated.
Keyword Oncology
Oncology
ONCOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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