Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial

Ferreri, Andres J. M., Ponzoni, Maurilio, Guidoboni, Massimo, Resti, Antonio Giordano, Politi, Letterio S., Cortelazzo, Sergio, Demeter, Judit, Zallio, Francesco, Palmas, Angelo, Muti, Giuliana, Dognini, Giuseppina P., Pasini, Elisa, Lettini, Antonia Anna, Sacchetti, Federico, De Conciliis, Carlo, Doglioni, Claudio and Dolcetti, Riccardo (2006) Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial. JNCI Journal of the National Cancer Institute, 98 19: 1375-1382. doi:10.1093/jnci/djj373


Author Ferreri, Andres J. M.
Ponzoni, Maurilio
Guidoboni, Massimo
Resti, Antonio Giordano
Politi, Letterio S.
Cortelazzo, Sergio
Demeter, Judit
Zallio, Francesco
Palmas, Angelo
Muti, Giuliana
Dognini, Giuseppina P.
Pasini, Elisa
Lettini, Antonia Anna
Sacchetti, Federico
De Conciliis, Carlo
Doglioni, Claudio
Dolcetti, Riccardo
Title Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial
Journal name JNCI Journal of the National Cancer Institute   Check publisher's open access policy
ISSN 0027-8874
1460-2105
Publication date 2006-10-04
Sub-type Article (original research)
DOI 10.1093/jnci/djj373
Open Access Status Not yet assessed
Volume 98
Issue 19
Start page 1375
End page 1382
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background: An association between ocular adnexal MALT lymphoma (OAL) and Chlamydia psittaci (Cp) infection has been proposed, and recent reports suggest that doxycycline treatment causes tumor regression in patients with Cp-related OAL. The effectiveness of doxycycline treatment in Cp-negative OAL has not been tested.

Methods: In a prospective trial, 27 OAL patients (15 newly diagnosed and 12 having experienced relapse) were given a 3-week course of doxycycline therapy. Objective lymphoma response was assessed by computerized tomography scans or magnetic resonance imaging at 1, 3, and 6 months after the conclusion of therapy and every 6 months during follow-up. Cp infection in patients was determined by touchdown enzyme time-release polymerase chain reaction (TETR-PCR). Statistical tests were two-sided.

Results: Eleven patients were Cp DNA-positive and 16 were Cp DNA negative. Doxycycline was well tolerated. At a median follow-up of 14 months, lymphoma regression was complete in six patients, and a partial response (≥50% reduction of all measurable lesions) was observed in seven patients (overall response rate [complete and partial responses] = 48%). Lymphoma regression was observed in both Cp DNA-positive patients (seven of 11 experienced regression) and Cp DNA-negative patients (six of 16 experienced regression) (64% versus 38%; P = .25, Fisher's exact test). The three patients with regional lymphadenopathies and three of the five patients with bilateral disease achieved objective response. In relapsed patients, response was observed both in previously irradiated and nonirradiated patients. The 2-year failure-free survival rate among the doxycycline-treated patients was 66% (95% confidence interval = 54 to 78), and 20 of the 27 patients were progression free.

Conclusions: Doxycycline is a fast, safe, and active therapy for Cp DNA-positive OAL that was effective even in patients with multiple failures involving previously irradiated areas or regional lymphadenopathies. The responses observed in PCR-negative OAL may suggest a need for development of more sensitive methods for Cp detection and investigation of the potential role of other doxycycline-sensitive bacteria.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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