Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease

Dolcetti, R., Boiocchi, M., Gloghini, A. and Carbone, A. (2001) Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease. European Journal of Cancer, 37 10: 1276-1287. doi:10.1016/S0959-8049(01)00105-8


Author Dolcetti, R.
Boiocchi, M.
Gloghini, A.
Carbone, A.
Title Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
1879-0852
Publication date 2001-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0959-8049(01)00105-8
Open Access Status Not yet assessed
Volume 37
Issue 10
Start page 1276
End page 1287
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Abstract Compared with the cases in the general population, Hodgkin's disease (HD) arising in the HIV setting shows distinctive features in terms of epidemiology, aetiopathogenesis, histopathology and clinical behaviour. Although HD does not represent an AIDS-defining condition, recent evidence consistently indicates that HIV-infected individuals have a significantly increased risk of developing HD. HIV-related HD is characterised by the preponderance of aggressive histological subtypes, advanced stage at presentation, and highly malignant clinical course. Moreover, unlike HD in the general population, the large majority of HIV-related HD cases are pathogenetically linked to Epstein-Barr virus (EBV), with rates of EBV positivity ranging from 80 to 100%. Hodgkin and Reed-Sternberg cells of these cases invariably show a strong expression of the EBV-encoded latent membrane protein-1 (LMP-1), which functions as a constitutively activated tumour necrosis factor (TNF) receptor-like molecule. Usurpation of physiologically relevant pathways by LMP-1 may lead to the simultaneous or sequential activation of signalling pathways involved in the promotion of cell activation, growth, and survival, contributing thus to most of the features of HIV-related HD.
Keyword CD40
Epstein-Barr virus
HIV
Hodgkin's disease
LMP-1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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