Epstein-Barr virus and telomerase: from cell immortalization to therapy

Dolcetti, Riccardo, Giunco, Silvia, Dal Col, Jessica, Celeghin, Andrea, Mastorci, Katy and De Rossi, Anita (2014) Epstein-Barr virus and telomerase: from cell immortalization to therapy. Infectious Agents and Cancer, 9 1: . doi:10.1186/1750-9378-9-8


Author Dolcetti, Riccardo
Giunco, Silvia
Dal Col, Jessica
Celeghin, Andrea
Mastorci, Katy
De Rossi, Anita
Title Epstein-Barr virus and telomerase: from cell immortalization to therapy
Journal name Infectious Agents and Cancer   Check publisher's open access policy
ISSN 1750-9378
Publication date 2014-02-26
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1750-9378-9-8
Open Access Status DOI
Volume 9
Issue 1
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Overcoming cellular senescence is strictly required for virus-driven tumors, including those associated with Epstein-Barr virus (EBV). This critical step is successfully accomplished by EBV through TERT expression and telomerase activation in infected cells. We herein review the complex interplay between EBV and TERT/telomerase in EBV-driven tumorigenesis. Evidence accumulated so far clearly indicates that elucidation of this issue may offer promising opportunities for the design of innovative treatment modalities for EBV-associated malignancies. Indeed, several therapeutic strategies for telomerase inhibition have been developed and are being investigated in clinical trials. In this respect, our recent finding that TERT inhibition sensitizes EBV+ lymphoma cells to antivirals through activation of EBV lytic replication is particularly promising and provides a rationale for the activation of clinical studies aimed at assessing the effects of combination therapies with TERT inhibitors and antivirals for the treatment of EBV-associated malignancies.
Keyword Antivirals
Cancer
Epstein-Barr virus
Lymphoma
Lytic replication
Telomerase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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