Chlamydial infection: the link with ocular adnexal lymphomas

Ferreri, Andres J. M., Dolcetti, Riccardo, Magnino, Simone, Doglioni, Claudio and Ponzoni, Pill (2009) Chlamydial infection: the link with ocular adnexal lymphomas. Nature Reviews Clinical Oncology, 6 11: 658-669. doi:10.1038/nrclinonc.2009.147

Author Ferreri, Andres J. M.
Dolcetti, Riccardo
Magnino, Simone
Doglioni, Claudio
Ponzoni, Pill
Title Chlamydial infection: the link with ocular adnexal lymphomas
Journal name Nature Reviews Clinical Oncology   Check publisher's open access policy
ISSN 1759-4774
Publication date 2009-11-01
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrclinonc.2009.147
Open Access Status Not yet assessed
Volume 6
Issue 11
Start page 658
End page 669
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Chlamydiae are obligate intracellular bacteria that grow in eukaryotic cells and cause a wide spectrum of diseases. They can establish persistent infections, are mitogenic in vitro, promote polyclonal cell proliferation in vivo and induce resistance to apoptosis in infected cells—properties that might contribute to tumorigenesis. In fact, Chlamydophila psittaci (Cp) has been linked to the development and maintenance of ocular adnexal marginal zone B-cell lymphoma (OAMZL). In this indolent malignancy, Cp is transported by monocytes and macrophages and causes both local and systemic infection. Cp elementary bodies are viable and infectious in the conjunctiva and peripheral blood of patients with OAMZL. Bacterial eradication with antibiotic therapy is often followed by lymphoma regression. Despite recent advances in the understanding of this bacterium–lymphoma association, several questions remain unanswered. For instance, prevalence variations among different geographical areas and related diagnostic and therapeutic implications remain a major investigational issue. We will focus on clinical and therapeutic implications of chlamydial infections in patients with lymphomas and summarize the current knowledge on the association between Cp infection and OAMZL. Available data on the epidemiology, biology and pathogenesis of this association are analyzed and new investigative and clinical approaches are discussed.
Keyword Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 037874
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
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