Latent membrane protein 1 deletion mutants accumulate in Reed-Sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma

Guidoboni, Massimo, Ponzoni, Maurilio, Caggiari, Laura, Lettini, Antonia A., Vago, Luca, De Re, Valli, Gloghini, Annunziata, Zancai, Paola, Carbone, Antonino, Boiocchi, Mauro and Dolcetti, Riccardo (2005) Latent membrane protein 1 deletion mutants accumulate in Reed-Sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma. Journal of Virology, 79 4: 2643-2649. doi:10.1128/JVI.79.4.2643-2649.2005

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ374319_OA.pdf Full text (open access) application/pdf 330.43KB 0

Author Guidoboni, Massimo
Ponzoni, Maurilio
Caggiari, Laura
Lettini, Antonia A.
Vago, Luca
De Re, Valli
Gloghini, Annunziata
Zancai, Paola
Carbone, Antonino
Boiocchi, Mauro
Dolcetti, Riccardo
Title Latent membrane protein 1 deletion mutants accumulate in Reed-Sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2005-02-01
Sub-type Article (original research)
DOI 10.1128/JVI.79.4.2643-2649.2005
Open Access Status File (Publisher version)
Volume 79
Issue 4
Start page 2643
End page 2649
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract The origin and biological significance of deletions at the 3′ end of the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) gene are still controversial. We herein demonstrate that LMP-1 deletion mutants are highly associated with human immunodeficiency virus-related Hodgkin's lymphoma (HIV-HL) of Italian patients (29 of 31 cases; 93.5%), a phenomenon that is not due to a peculiar distribution of EBV strains in this area. In fact, although HIV-HL patients are infected by multiple EBV variants, we demonstrate that LMP-1 deletion mutants preferentially accumulate within neoplastic tissues. Subcloning and sequencing of the 3′ LMP-1 ends of two HIV-HL genes in which both variants were present showed the presence of molecular signatures suggestive of a likely derivation of the LMP-1 deletion mutant from a nondeletion ancestor. This phenomenon likely occurs within tumor cells in vivo, as shown by the detection of both LMP-1 variants in single microdissected Reed-Sternberg cells, and may at least in part explain the high prevalence of LMP-1 deletions associated with HIV-HL.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 28 Nov 2015, 05:40:04 EST by System User on behalf of Learning and Research Services (UQ Library)