Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: New immunobiological and molecular insights on a long-standing etiopathogenic association

Dolcetti, R and Menezes, J (2003) Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: New immunobiological and molecular insights on a long-standing etiopathogenic association. Advances in Cancer Research, 87 127-157. doi:10.1016/S0065-230X(03)87191-9


Author Dolcetti, R
Menezes, J
Title Epstein-Barr virus and undifferentiated nasopharyngeal carcinoma: New immunobiological and molecular insights on a long-standing etiopathogenic association
Journal name Advances in Cancer Research   Check publisher's open access policy
ISSN 0065-230X
Publication date 2003-01-01
Year available 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0065-230X(03)87191-9
Open Access Status Not yet assessed
Volume 87
Start page 127
End page 157
Total pages 31
Publisher ACADEMIC PRESS INC
Language eng
Subject 1306 Cancer Research
2730 Oncology
Abstract Undifferentiated nasopharyngeal carcinoma (UCNT) is characterized by its unique epidemiologic, immunobiologic, virologic, and clinicopathologic features. Aside from environmental risk factors and possible genetic susceptibility, infection by the Epstein- Barr virus (EBV) constitutes a well-documented link for the development of UCNT. However, despite the fact that UCNT is the human tumor associated most consistently with EBV, the role played by this virus in the pathogenesis of UCNT is still largely speculative and is a matter of ongoing debate. The purpose of this article is to review recent advances, particularly at the immunovirological and molecular levels, linking EBV infection to UCNT, and to discuss those aspects that may be of relevance for a better diagnosis and/or prognosis of this tumor, as well as for development of novel therapeutic strategies.
Keyword Oncology
Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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