Simian virus 40 sequences in human lymphoblastoid B-cell lines

Dolcetti, Riccardo, Martini, Fernanda, Quaia, Michele, Gloghini, Annunziata, Vignocchi, Beatrice, Cariati, Roberta, Martinelli, Marcella, Carbone, Antonino, Boiocchi, Mauro and Tognon, Mauro (2003) Simian virus 40 sequences in human lymphoblastoid B-cell lines. Journal of Virology, 77 2: 1595-1597. doi:10.1128/JVI.77.2.1595-1597.2003

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Author Dolcetti, Riccardo
Martini, Fernanda
Quaia, Michele
Gloghini, Annunziata
Vignocchi, Beatrice
Cariati, Roberta
Martinelli, Marcella
Carbone, Antonino
Boiocchi, Mauro
Tognon, Mauro
Title Simian virus 40 sequences in human lymphoblastoid B-cell lines
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1128/JVI.77.2.1595-1597.2003
Open Access Status File (Publisher version)
Volume 77
Issue 2
Start page 1595
End page 1597
Total pages 3
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
Human Epstein-Barr virus-immortalized lymphoblastoid B-cell lines tested positive by PCR for simian virus 40 (SV40) DNA (22 of 42 cell lines, 52.3%). B lymphocytes or tissues from which B-cell lines derived were also SV40 positive. In situ hybridization showed that SV40 DNA was present in the nucleus of a small fraction (1/250) of cells. SV40 T-antigen mRNA was detected by reverse transcription-PCR. Lymphoblastoid B-cell lines (n = 4) infected with SV40 remained SV40 positive for 4 to 6 months. SV40-positive B-cell lines were more tumorigenic in SCID mice than were SV40-negative cell lines (4 of 5 [80%] SV40-positive cell lines versus 2 of 4 [50%] SV40-negative cell lines). These results suggest that SV40 may play a role in the early phases of human lymphomagenesis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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