Chlamydophila psittaci subclinical infection in chronic polyarthritis

Fabris, M., De Vita, S., Pasini, E., Quartuccio, L., Pontarini, E., Lombardi, S., Fabro, C., Sarzi-Puttini, P. C., Pellerito, R., Benucci, M., Morassi, P., Biasi, D., Curcio, F. and Dolcetti, R. (2011) Chlamydophila psittaci subclinical infection in chronic polyarthritis. Clinical and Experimental Rheumatology, 29 6: 977-982.

Author Fabris, M.
De Vita, S.
Pasini, E.
Quartuccio, L.
Pontarini, E.
Lombardi, S.
Fabro, C.
Sarzi-Puttini, P. C.
Pellerito, R.
Benucci, M.
Morassi, P.
Biasi, D.
Curcio, F.
Dolcetti, R.
Title Chlamydophila psittaci subclinical infection in chronic polyarthritis
Formatted title
Chlamydophila psittaci subclinical infection in chronic polyarthritis
Journal name Clinical and Experimental Rheumatology   Check publisher's open access policy
ISSN 0392-856X
1593-098X
Publication date 2011-11-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 29
Issue 6
Start page 977
End page 982
Total pages 6
Place of publication Ospedaletto, Italy
Publisher Pacini Editore
Language eng
Formatted abstract
OBJECTIVES:
Recent evidence indicates that Chlamydophila psittaci (Cp) may establish chronic infections, which may promote autoimmunity and/or B cell lymphoproliferation.
METHODS:
The presence of a subclinical Cp infection was investigated in 293 patients with chronic inflammatory polyarthritis, including 175 patients with rheumatoid factor (RF)-positive and/or anti-CCP-positive rheumatoid arthritis (RA) and 118 with seronegative polyarthritis (46 RF-negative/anti-CCP-negative RA, 36 psoriatic arthritis and 36 undifferentiated spondyloarthritis). One hundred and eighty-five healthy controls were also investigated. The presence of Cp infection was assessed in peripheral blood mononuclear cells using several PCR protocols targeting different regions of the Cp genome (16S-23S spacer rRNA, OMP-A, and Gro-EL). The DNA of other Chlamydia species (C. Pneumoniae and C. Trachomatis) was also investigated. Amplicons were sequenced to confirm the specificity of PCR products.
RESULTS:
The presence of a subclinical chronic Cp infection was observed in a significantly higher percentage of patients with chronic polyarthritis (38/293; 13%) compared to healthy controls (1/185, 0.5%; OR=27.4, 95%CI:3.73-201.6, p<0.0001). Furthermore, the prevalence of Cp was higher in seronegative polyarthritis (23/118; 19.5%) than in seropositive RA patients (15/175; 7.4%; OR=2.58, 95%CI: 1.28-5.19, p=0.0078). The highest prevalence of Cp infection was found in RF/anti-CCP double-negative RA patients (13/46, 28.3%), followed by patients with psoriatic arthritis (6/36; 16.7%). No differences in age, sex, disease duration and undergoing therapies were noticed between Cp-positive and Cp-negative patients; nor between seropositive and seronegative patients.
CONCLUSIONS:
Cp may be an infectious trigger possibly involved in the pathogenesis of a fraction of inflammatory polyarthritis, particularly in seronegative patients.
Keyword Chlamydophila psittaci
Autoimmunity
Rheumatoid arthritis
Pathogenesis
Rheumatoid factor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Issue: November-December 2011

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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