Nuclear oncogene amplification or rearrangement is not involved in human colorectal malignancies

Dolcetti, R, DE Re, V, Viel, A, Pistello, M, Tavian, M and Boiocchi, M (1988) Nuclear oncogene amplification or rearrangement is not involved in human colorectal malignancies. European Journal of Cancer and Clinical Oncology, 24 8: 1321-1328. doi:10.1016/0277-5379(88)90223-4


Author Dolcetti, R
DE Re, V
Viel, A
Pistello, M
Tavian, M
Boiocchi, M
Title Nuclear oncogene amplification or rearrangement is not involved in human colorectal malignancies
Journal name European Journal of Cancer and Clinical Oncology   Check publisher's open access policy
ISSN 0277-5379
Publication date 1988-01-01
Sub-type Article (original research)
DOI 10.1016/0277-5379(88)90223-4
Volume 24
Issue 8
Start page 1321
End page 1328
Total pages 8
Language eng
Subject 2730 Oncology
Abstract We have examined 44 cases of human colonic and rectal carcinomas for structural rearrangement and amplification of c-myc, N-myc, L-myc, c-myb and p53 oncogenes. DNA hybridization showed evidence of c-myc amplification in only one of the samples tested. In addition, the same tumour also showed a rearrangement immediately 3′ to the c-myc locus. No rearrangement could be found at the c-myc locus in the other 43 cases. Moreover, our molecular analysis of N-myc, L-myc, c-myb and p53 genes indicated no relevant alteration of the copy number and/or genomic structure of these nuclear oncogenes. Thus, at least in human colorectal malignancies, it is unlikely that nuclear oncogene structural alterations and/or amplification plays a major role in tumour induction or progression.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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