Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa

Ferreri, A. J. M., Viale, E., Guidoboni, M., Resti, A. G., De Conciliis, C., Politi, L., Lettini, A. A., Sacchetti, F., Dolcetti, R., Doglioni, C. and Ponzoni, M. (2006) Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa. Annals of Oncology, 17 5: 769-772. doi:10.1093/annonc/mdl027

Author Ferreri, A. J. M.
Viale, E.
Guidoboni, M.
Resti, A. G.
De Conciliis, C.
Politi, L.
Lettini, A. A.
Sacchetti, F.
Dolcetti, R.
Doglioni, C.
Ponzoni, M.
Title Clinical implications of hepatitis C virus infection in MALT-type lymphoma of the ocular adnexa
Journal name Annals of Oncology   Check publisher's open access policy
ISSN 0923-7534
Publication date 2006-05-01
Sub-type Article (original research)
DOI 10.1093/annonc/mdl027
Open Access Status Not yet assessed
Volume 17
Issue 5
Start page 769
End page 772
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background: A pathogenic link between hepatitis C virus (HCV) and MALT-type lymphomas has been suggested. However, studies assessing the role of HCV infection separately in different forms of MALT lymphomas are not available.

Patients and methods: The prevalence and clinical implications of HCV seropositivity were analyzed in 55 patients with ocular adnexa lymphoma (OAL) of MALT-type.

Results: HCV seropositivity was detected in seven (13%) patients. At presentation, HCV infection was significantly associated with concomitant extra-orbital disease, lymph node dissemination and involvement of additional extranodal organs. HCV seropositivity was associated also with a higher relapse rate and worse progression-free survival. In fact, 16 patients experienced relapse after first-line treatment: five (71%) were HCV-seropositive and 11 (23%) were HCV-seronegative, with a median TTP of 31 and 50+ months (P = 0.01), and a 5-year progression-free survival of 43 ± 18% and 77 ± 7% (P = 0.005), respectively. HCV-seropositive patients experienced frequent relapses despite further lines of therapy; relapses were systemic in all cases but one; multiple subcutaneous nodules were common at relapse.

Conclusions: HCV seropositivity is present in 13% of OAL of MALT-type. Concomitant HCV infection is associated with more disseminated disease and aggressive behavior in OAL, with a consequent potential negative impact in patients managed with radiotherapy alone.
Keyword Hepatitis C virus
Infectious agents
MALT lymphoma
Ocular adnexal lymphoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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