Exploiting the interplay between innate and adaptive immunity to improve immunotherapeutic strategies for Epstein-Barr-virus-driven disorders

Martorelli, Debora, Muraro, Elena, Merlo, Anna, Turrini, Riccardo, Fae, Damiana Antonia, Rosato, Antonio and Dolcetti, Riccardo (2012) Exploiting the interplay between innate and adaptive immunity to improve immunotherapeutic strategies for Epstein-Barr-virus-driven disorders. Clinical and Developmental Immunology, 2012 . doi:10.1155/2012/931952


Author Martorelli, Debora
Muraro, Elena
Merlo, Anna
Turrini, Riccardo
Fae, Damiana Antonia
Rosato, Antonio
Dolcetti, Riccardo
Title Exploiting the interplay between innate and adaptive immunity to improve immunotherapeutic strategies for Epstein-Barr-virus-driven disorders
Journal name Clinical and Developmental Immunology   Check publisher's open access policy
ISSN 1740-2522
2314-7156
Publication date 2012-01-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2012/931952
Open Access Status DOI
Volume 2012
Total pages 20
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Language eng
Abstract The recent demonstration that immunotherapeutic approaches may be clinically effective for cancer patients has renewed the interest for this strategy of intervention. In particular, clinical trials using adoptive T-cell therapies disclosed encouraging results, particularly in the context of Epstein-Barr-virus- (EBV-) related tumors. Nevertheless, the rate of complete clinical responses is still limited, thus stimulating the development of more effective therapeutic protocols. Considering the relevance of innate immunity in controlling both infections and cancers, innovative immunotherapeutic approaches should take into account also this compartment to improve clinical efficacy. Evidence accumulated so far indicates that innate immunity effectors, particularly NK cells, can be exploited with therapeutic purposes and new targets have been recently identified. We herein review the complex interactions between EBV and innate immunity and summarize the therapeutic strategies involving both adaptive and innate immune system, in the light of a fruitful integration between these immunotherapeutic modalities for a better control of EBV-driven tumors.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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