Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas

Dolcetti, Riccardo (2015) Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas. Seminars in Cancer Biology, 34 58-69. doi:10.1016/j.semcancer.2015.04.006


Author Dolcetti, Riccardo
Title Cross-talk between Epstein-Barr virus and microenvironment in the pathogenesis of lymphomas
Journal name Seminars in Cancer Biology   Check publisher's open access policy
ISSN 1096-3650
1044-579X
Publication date 2015-10-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcancer.2015.04.006
Open Access Status Not Open Access
Volume 34
Start page 58
End page 69
Total pages 12
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Subject 1306 Cancer Research
2700 Medicine
Abstract Epstein-Bar virus (EBV) is known to directly drive the neoplastic transformation of lymphoid cells resulting in the development of a variety of lymphoproliferative disorders. Emerging evidence however indicates that this final outcome is also related to the ability of EBV to shape microenvironment making it more conducive to cell transformation. Indeed, EBV up-regulates the production of several soluble factors promoting the growth and/or the survival of lymphoid cells and orchestrates a variety of complex mechanisms favoring their escape from anti-tumor immune responses. Furthermore, EBV-infected B lymphocytes actively secrete exosomes and recent investigation is now shedding light on the content and functional impact that these bioactive vesicles may have in bystander recipient cells. The complex interplay existing between EBV-carrying lymphoid cells and tumor microenvironment is now offering attractive targets of therapy that can be exploited to improve current therapeutic strategies for EBV-driven lymphoid malignancies.
Keyword Epstein-Barr virus
Exosome
Immune response
Lymphoma
Microenvironment
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID 14287
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
UQ Diamantina Institute Publications
 
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