Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation

Dagklis, A., Ponzoni, M., Govi, S., Cangi, M. G., Pasini, E., Charlotte, F., Vino, A., Doglioni, C., Davi, F., Lossos, I. S., Ntountas, I., Papadaki, T., Dolcetti, R., Ferreri, A. J. M., Stamatopoulos, K. and Ghia, P. (2012) Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation. Leukemia, 26 4: 814-821. doi:10.1038/leu.2011.276

Author Dagklis, A.
Ponzoni, M.
Govi, S.
Cangi, M. G.
Pasini, E.
Charlotte, F.
Vino, A.
Doglioni, C.
Davi, F.
Lossos, I. S.
Ntountas, I.
Papadaki, T.
Dolcetti, R.
Ferreri, A. J. M.
Stamatopoulos, K.
Ghia, P.
Title Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation
Journal name Leukemia   Check publisher's open access policy
ISSN 0887-6924
Publication date 2012-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/leu.2011.276
Open Access Status Not yet assessed
Volume 26
Issue 4
Start page 814
End page 821
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Evidence from certain geographical areas links lymphomas of the ocular adnexa marginal zone B-cell lymphomas (OAMZL) with Chlamydophila psittaci (Cp) infection, suggesting that lymphoma development is dependent upon chronic stimulation by persistent infections. Notwithstanding that, the actual immunopathogenetical mechanisms have not yet been elucidated. As in other B-cell lymphomas, insight into this issue, especially with regard to potential selecting ligands, could be provided by analysis of the immunoglobulin (IG) receptors of the malignant clones. To this end, we studied the molecular features of IGs in 44 patients with OAMZL (40% Cp-positive), identifying features suggestive of a pathogenic mechanism of autoreactivity. Herein, we show that lymphoma cells express a distinctive IG repertoire, with electropositive antigen (Ag)-binding sites, reminiscent of autoantibodies (auto-Abs) recognizing DNA. Additionally, five (11%) cases of OAMZL expressed IGs homologous with autoreactive Abs or IGs of patients with chronic lymphocytic leukemia, a disease known for the expression of autoreactive IGs by neoplastic cells. In contrast, no similarity with known anti-Chlamydophila Abs was found. Taken together, these results strongly indicate that OAMZL may originate from B cells selected for their capability to bind Ags and, in particular, auto-Ags. In OAMZL associated with Cp infection, the pathogen likely acts indirectly on the malignant B cells, promoting the development of an inflammatory milieu, where auto-Ags could be exposed and presented, driving proliferation and expansion of self-reactive B cells.
Keyword Chlamydia psittaci
Ocular adnexa lymphoma
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 09SYN-13-880
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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