A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci

Boiocchi, M, Dolcetti, R, Maestro, R, Feriotto, G, Rizzo, S, DE Re, V and Sonego, F (1990) A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci. Leukemia Research, 14 6: 549-+. doi:10.1016/0145-2126(90)90007-V


Author Boiocchi, M
Dolcetti, R
Maestro, R
Feriotto, G
Rizzo, S
DE Re, V
Sonego, F
Title A coordinated proto-oncogene expression characterizes MCF 247 murine leukemia virus-induced T-cell lymphomas irrespectively of proviral insertion affecting myc loci
Journal name Leukemia Research   Check publisher's open access policy
ISSN 0145-2126
Publication date 1990-01-01
Sub-type Article (original research)
DOI 10.1016/0145-2126(90)90007-V
Volume 14
Issue 6
Start page 549
End page +
Total pages 1
Language eng
Subject 1306 Cancer Research
2720 Hematology
2730 Oncology
Abstract Proto-oncogene transcriptional activation was analyzed in a group of MCF 247 MuLv-induced T-cell lymphomas to identify transformation-specific gene activations and determine whether the proviral insertion near amyc gene could promote a peculiar mechanism of transformation through a differential proto-oncogene expression pattern. Of the six lymphomas analyzed, three showed the MCF 247 provirus integrated within the N-myc locus, one carried the provirus integrated near c-myc, whereas for the remaining two, no evidence of proviral integrations in any of the knownmyc loci was obtained. Independently of the integrative events, the pattern of proto-oncogene expression was almost identical in all six lymphomas. These findings seem to rule out the existence of a peculiar pathway of transformation associated with the proviral insertion near amyc locus. Moreover, the transcription pattern observed was qualitatively identical to that displayed by normal thymocytes; only quantitative differences in c- or N-myc, c-myb and Ha-ras were observed. These results suggest that the T-cell proto-oncogene activation program is not qualitatively affected by the transforming event(s).
Keyword lymphoma
Proto-oncogene
proviral insertion
retrovirus
T-cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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