Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae

Dolcetti, R., Serraino, D., Dognini, G., Govi, S., Crocchiolo, R., Ghia, P., Pasini, E., Ponzoni, M., Talamini, R., De Paoli, P., Doglioni, C. and Ferreri, A. J. M. (2012) Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae. British Journal of Cancer, 106 5: 966-969. doi:10.1038/bjc.2012.2

Author Dolcetti, R.
Serraino, D.
Dognini, G.
Govi, S.
Crocchiolo, R.
Ghia, P.
Pasini, E.
Ponzoni, M.
Talamini, R.
De Paoli, P.
Doglioni, C.
Ferreri, A. J. M.
Title Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
Publication date 2012-02-28
Year available 2012
Sub-type Article (original research)
DOI 10.1038/bjc.2012.2
Open Access Status DOI
Volume 106
Issue 5
Start page 966
End page 969
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Background: Ocular adnexal marginal zone B-cell lymphoma (OAMZL) has been associated with Chlamydophila psittaci, an infection that may be transmitted by carrier animals. However, it is still unclear whether exposure to animals affects the risk of OAMZL in comparison with other lymphoma histotypes. We therefore investigated the role of professional and/or domestic exposures to animals in the occurrence of OAMZL, as compared with other types of lymphoma.

Methods: A hospital-based case-control study was carried out on 43 consecutive OAMZL patients (cases) and 87 consecutive patients with nodal non-Hodgkin's lymphomas (NHLs; controls). Multiple logistic regression (MLR) odds ratios (ORs), and 95% confidence intervals (CIs) were used to estimate the association between exposures to animals and OAMZL risk.

Results:A higher proportion of cases reported a lifetime exposure to household animals (79.1% vs 64.4% among controls), with a non-statistical significant MLR-OR of 2.18 (95% CI: 0.85-5.62). The OAMZL cases more frequently reported a history of occupation in breeding and/or slaughtering than controls (34.9% vs 6.9%), with an overall increased risk of 7.69 (95%CI: 2.65-22.34).

Conclusion: These results indicate that, compared with nodal NHLs, the risk of OAMZL is markedly increased by contact with animals, particularly by occupational exposures.
Keyword Animal exposure
Chlamydophila psittaci
Non-Hodgkin's lymphomas ocular adnexal marginal zone B-cell lymphoma epidemiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1031
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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