Incidence and risk factors for clozapine-induced myocarditis and cardiomyopathy at a regional mental health service in Australia

Youssef, Daniel L., Narayanan, Pradeep and Gill, Neeraj (2015) Incidence and risk factors for clozapine-induced myocarditis and cardiomyopathy at a regional mental health service in Australia. Australasian Psychiatry, 24 2: 1-6. doi:10.1177/1039856215604480


Author Youssef, Daniel L.
Narayanan, Pradeep
Gill, Neeraj
Title Incidence and risk factors for clozapine-induced myocarditis and cardiomyopathy at a regional mental health service in Australia
Journal name Australasian Psychiatry   Check publisher's open access policy
ISSN 1440-1665
1039-8562
Publication date 2015-09-23
Year available 2016
Sub-type Article (original research)
DOI 10.1177/1039856215604480
Open Access Status Not Open Access
Volume 24
Issue 2
Start page 1
End page 6
Total pages 6
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
Objective: To determine the incidence of clozapine-induced myocarditis and cardiomyopathy and identify risk factors.

Method: A cohort of 129 patients initiated on clozapine at Toowoomba Mental Health Service from year 2000 until 2011 was examined to evaluate cases of myocarditis and cardiomyopathy. Risk factors were analysed using multivariable logistic regression.

Results: The incidence of clozapine-induced myocarditis and cardiomyopathy was 3.88% and 4.65% (or 2.26 per 100 patient years), respectively. A significant association was identified between clozapine-induced myocarditis and SSRI use (p = 0.043). Subclinical cardiomyopathy was identified in the absence of symptoms in the majority of cases.

Conclusions: These results illustrate a high incidence of clozapine-induced myocarditis as well as cardiomyopathy, reinforcing the need for a standardised, mandatory monitoring scheme. Concomitant SSRI use as one such potential predictor merits further study.
Keyword Clozapine
Myocarditis
Cardiomyopathy
Incidence
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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Created: Fri, 27 Nov 2015, 21:14:29 EST by Jacky Cribb on behalf of Learning and Research Services (UQ Library)