Direct transcriptional reprogramming to nephron progenitors

Vanslambrouck, J. M. and Little, M. H. (2015) Direct transcriptional reprogramming to nephron progenitors. Current Opinion in Genetics and Development, 34 10-16. doi:10.1016/j.gde.2015.06.001


Author Vanslambrouck, J. M.
Little, M. H.
Title Direct transcriptional reprogramming to nephron progenitors
Journal name Current Opinion in Genetics and Development   Check publisher's open access policy
ISSN 0959-437X
1879-0380
Publication date 2015-10-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.gde.2015.06.001
Open Access Status Not Open Access
Volume 34
Start page 10
End page 16
Total pages 7
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract The direct reprogramming of one cell fate to another represents an attractive option for the generation of specific endpoints for cellular therapy. This appears to require both the reactivation of critical transcription factor regulatory networks and chromatin remodelling. The direct reprogramming of mature renal epithelial cell lines to a nephron progenitor state has been reported. However, our limited knowledge of the optimal growth conditions to maintain this state remains a challenge for their therapeutic application. Here we examine whether nephron progenitors as an endpoint of direct reprogramming have been suitably defined and whether alternative options for reprogramming to kidney exist.
Formatted abstract
The direct reprogramming of one cell fate to another represents an attractive option for the generation of specific endpoints for cellular therapy. This appears to require both the reactivation of critical transcription factor regulatory networks and chromatin remodelling. The direct reprogramming of mature renal epithelial cell lines to a nephron progenitor state has been reported. However, our limited knowledge of the optimal growth conditions to maintain this state remains a challenge for their therapeutic application. Here we examine whether nephron progenitors as an endpoint of direct reprogramming have been suitably defined and whether alternative options for reprogramming to kidney exist.
Keyword Cell Biology
Genetics & Heredity
Cell Biology
Genetics & Heredity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2016 Collection
Institute for Molecular Bioscience - Publications
 
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