Magnitude of PD-1, PD-L1 and T lymphocyte expression on tissue from castration-resistant prostate adenocarcinoma: an exploratory analysis

Massari, Francesco, Ciccarese, Chiara, Calio, Anna, Munari, Enrico, Cima, Luca, Porcaro, Antonio Benito, Novella, Giovanni, Artibani, Walter, Sava, Teodoro, Eccher, Albino, Ghimenton, Claudio, Bertoldo, Francesco, Scarpa, Aldo, Sperandio, Nicola, Porta, Camillo, Bronte, Vincenzo, Chilosi, Marco, Bogina, Giuseppe, Zamboni, Giuseppe, Tortora, Giampaolo, Samaratunga, Hemamali, Martignoni, Guido and Brunelli, Matteo (2015) Magnitude of PD-1, PD-L1 and T lymphocyte expression on tissue from castration-resistant prostate adenocarcinoma: an exploratory analysis. Targeted Oncology, 1-7. doi:10.1007/s11523-015-0396-3


Author Massari, Francesco
Ciccarese, Chiara
Calio, Anna
Munari, Enrico
Cima, Luca
Porcaro, Antonio Benito
Novella, Giovanni
Artibani, Walter
Sava, Teodoro
Eccher, Albino
Ghimenton, Claudio
Bertoldo, Francesco
Scarpa, Aldo
Sperandio, Nicola
Porta, Camillo
Bronte, Vincenzo
Chilosi, Marco
Bogina, Giuseppe
Zamboni, Giuseppe
Tortora, Giampaolo
Samaratunga, Hemamali
Martignoni, Guido
Brunelli, Matteo
Title Magnitude of PD-1, PD-L1 and T lymphocyte expression on tissue from castration-resistant prostate adenocarcinoma: an exploratory analysis
Journal name Targeted Oncology   Check publisher's open access policy
ISSN 1776-260X
1776-2596
Publication date 2015-11-06
Sub-type Article (original research)
DOI 10.1007/s11523-015-0396-3
Open Access Status Not Open Access
Start page 1
End page 7
Total pages 7
Place of publication Paris, France
Publisher Springer-Verlag France
Collection year 2016
Language eng
Formatted abstract
Background and Aim: Recent therapeutic strategies for castration-resistant prostate cancer have focused on immunomodulation, especially the PD-1/PD-L1 pathway related to tumor-infiltrating lymphocytes. Few cases of castration-resistant prostate adenocarcinoma have been tested simultaneously for PD-1, PD-L1 and T lymphocytes in cancerous tissue. We quantified the PD-1/PD-L1 immune pathway and T lymphocyte infiltrates in a series of patients with castrate-resistant prostate adenocarcinoma.

Patients and Methods: Expression of PD-1, PD-L1, CD3 and FOXP3 was identified in tissue microarrays, with five tissue spots per patient from 16 patients over at least 5 years of follow-up. Two scores were defined. The first described the percentage of PD-1-positive T lymphocytes (CD3+): negative (0), <5 %; low (1+), 5–30 %; high (2+), >30 %. The second described PD-L1 staining intensity: 0 (no signal), 1+ (light signal), 2+ (high signal) in >50 % of neoplastic cells.

Results: Tumor-infiltrating T lymphocytes (CD3+) were seen in 11/16 cases (69 %). Nine of 16 cases expressed PD-1 (56 %), among which 19 % were scored 2+. Eight of 16 cases expressed PD-L1 (50 %), with 19 % scored as strong 2+. The subgroup with high PD1/PD-L1 also exhibited FOXP3 expression.

Conclusions: Approximately 19 % of patients in our series showed simultaneous high PD-1/PD-L1 immunoscores, and were the best candidates for receiving targeted anti-PD-1/PD-L1 immunotherapy, as determined using a tissue based rationale.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
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