Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats

Bhaswant, Maharshi, Fanning, Kent, Netzel, Michael, Mathai, Michael L., Panchal, Sunil K. and Brown, Lindsay (2015) Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats. Pharmacological Research, 102 208-217. doi:10.1016/j.phrs.2015.10.006

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Author Bhaswant, Maharshi
Fanning, Kent
Netzel, Michael
Mathai, Michael L.
Panchal, Sunil K.
Brown, Lindsay
Title Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats
Journal name Pharmacological Research   Check publisher's open access policy
ISSN 1096-1186
Publication date 2015-12-01
Sub-type Article (original research)
DOI 10.1016/j.phrs.2015.10.006
Open Access Status File (Author Post-print)
Volume 102
Start page 208
End page 217
Total pages 10
Place of publication London, United Kingdom
Publisher Academic Press
Language eng
Subject 3004 Pharmacology
Abstract Increased consumption of dark-coloured fruits and vegetables may mitigate metabolic syndrome. This study has determined the changes in metabolic parameters, and in cardiovascular and liver structure and function, following chronic administration of either cyanidin 3-glucoside (CG) or Queen Garnet plum juice (QG) containing cyanidin glycosides to rats fed either a corn starch (C) or a high-carbohydrate, high-fat (H) diet. Eight to nine-week-old male Wistar rats were randomly divided into six groups for 16-week feeding with C, C with CG or QG, H or H with CG or QG. C or H were supplemented with CG or QG at a dose of ∼8 mg/kg/day cyanidin glycosides from week 8 to 16. H rats developed signs of metabolic syndrome including visceral adiposity, impaired glucose tolerance, hypertension, cardiovascular remodelling, increased collagen depots in left ventricle, non-alcoholic fatty liver disease, increased plasma liver enzymes and increased inflammatory cell infiltration in the heart and liver. Both CG and QG reversed these cardiovascular, liver and metabolic signs. However, no intact anthocyanins or common methylated/conjugated metabolites could be detected in the plasma samples and plasma hippuric acid concentrations were unchanged. Our results suggest CG is the most likely mediator of the responses to QG but that further investigation of the pharmacokinetics of oral CG in rats is required.
Keyword Anthocyanins
Cyanidin 3-glucoside
Metabolic syndrome
Queen Garnet plum
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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