Experimental infection of peridomestic mammals with emergent H7N9 (A/Anhui/1/2013) influenza A virus: implications for biosecurity and wet markets

Root, J. Jeffrey, Bosco-Lauth, Angela M., Bielefeldt-Ohmann, Helle and Bowen, Richard A. (2016) Experimental infection of peridomestic mammals with emergent H7N9 (A/Anhui/1/2013) influenza A virus: implications for biosecurity and wet markets. Virology, 487 242-248. doi:10.1016/j.virol.2015.10.020


Author Root, J. Jeffrey
Bosco-Lauth, Angela M.
Bielefeldt-Ohmann, Helle
Bowen, Richard A.
Title Experimental infection of peridomestic mammals with emergent H7N9 (A/Anhui/1/2013) influenza A virus: implications for biosecurity and wet markets
Journal name Virology   Check publisher's open access policy
ISSN 1096-0341
0042-6822
1089-862X
Publication date 2016-01-01
Sub-type Article (original research)
DOI 10.1016/j.virol.2015.10.020
Open Access Status DOI
Volume 487
Start page 242
End page 248
Total pages 7
Place of publication Waltham, MA, United States
Publisher Academic Press
Language eng
Formatted abstract
During 2013, a novel avian-origin H7N9 influenza A virus (IAV) emerged in China and subsequently caused large economic and public health burdens. We experimentally infected three common peridomestic wild mammals with H7N9 (A/Anhui/1/2013) IAV. Striped skunks exhibited the highest burden of disease followed by raccoons and cottontail rabbits. Striped skunks also produced the highest levels of viral shedding (up to 106.4 PFU/mL nasal flush) followed by cottontail rabbits (up to 105.8 PFU/mL nasal flush) and raccoons (up to 105.2 PFU/mL nasal flush). Thus, various mammalian species, especially those that are peridomestic, could play a role in the epidemiology of emergent H7N9 IAV. Mammals should be accounted for in biosecurity plans associated with H7N9 and their presence in wet markets, dependent on species, could lead to increased transmission among interspecific species aggregations and may also pose an elevated zoonotic disease risk to visitors and workers of such markets.
Keyword Cottontail rabbit
Experimental infection
H7N9
Influenza A virus
Mammals
Mephitis
Pathology
Procyon
Raccoon
Shedding
Skunk
Sylvilagus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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