The key role of mitochondrial apoptotic pathway in the cytotoxic effect of mushroom extracts on cancer cells

Han, Mei, Ling, Ming-Tat and Chen, Jiezhong (2015) The key role of mitochondrial apoptotic pathway in the cytotoxic effect of mushroom extracts on cancer cells. Critical Reviews in Eukaryotic Gene Expression, 25 3: 253-258. doi:10.1615/CritRevEukaryotGeneExpr.2015014019


Author Han, Mei
Ling, Ming-Tat
Chen, Jiezhong
Title The key role of mitochondrial apoptotic pathway in the cytotoxic effect of mushroom extracts on cancer cells
Journal name Critical Reviews in Eukaryotic Gene Expression   Check publisher's open access policy
ISSN 1045-4403
2162-6502
Publication date 2015-09-01
Year available 2015
Sub-type Article (original research)
DOI 10.1615/CritRevEukaryotGeneExpr.2015014019
Open Access Status Not Open Access
Volume 25
Issue 3
Start page 253
End page 258
Total pages 6
Place of publication Danbury, CT United States
Publisher Begell House
Language eng
Abstract Mushroom extracts have been extensively studied for their medicinal effects. They can stimulate immune responses and thus have been explored in cancer treatment. Recently, it has also been shown that some mushroom extracts can produce direct cytotoxic effect on cancer cells. In this review, we summarize the cytotoxic effect of mushroom extracts in cancer treatment revealed by both in vitro and in vivo studies. We also summarize the current understanding of the mechanisms associated with such an effect with an emphasis on the mitochondrial apoptotic pathway. The recent finding that mushroom extracts have direct cytotoxic effects supplements their known immune stimulating effects. Thus, novel anticancer agents based on new findings from mushroom extracts may soon be added to the present pool of anticancer drugs. Specifically, we propose that nanodelivery of the bioactive compounds of mushroom extracts to mitochondria will further increase their potential treatment efficacy.
Keyword Mushroom extracts
Bcl-2
Bax
Akt
Nanodelivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Biomedical Sciences Publications
 
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