Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives

Krainz, Tanja, Chow, Sharon, Korica, Natasa, Bernhardt, Paul V., Boyle, Glen M., Parsons, Peter G., Davies, Huw M. L. and Williams, Craig M. (2015) Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives. European Journal of Organic Chemistry, 2016 1: 41-44. doi:10.1002/ejoc.201501271


Author Krainz, Tanja
Chow, Sharon
Korica, Natasa
Bernhardt, Paul V.
Boyle, Glen M.
Parsons, Peter G.
Davies, Huw M. L.
Williams, Craig M.
Title Rhodium-Catalyzed [4+3] Cycloaddition to Furans: Direct Access to Functionalized Bicyclo[5.3.0]decane Derivatives
Journal name European Journal of Organic Chemistry   Check publisher's open access policy
ISSN 1434-193X
1099-0690
Publication date 2015-11-13
Sub-type Article (original research)
DOI 10.1002/ejoc.201501271
Open Access Status Not Open Access
Volume 2016
Issue 1
Start page 41
End page 44
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH
Language eng
Formatted abstract
An efficient method to directly access the bicyclo[5.3.0]decane core was achieved by rhodium-catalyzed reaction of a novel donor–acceptor cyclopentenyl diazocarboxylate with a variety of furans. As this motif is commonly found within bioactive antitumor natural products, selected systems were further manipulated and evaluated against cancer cell lines sensitive to protein kinase C (PKC) activation.
Keyword Cycloaddition
Furans
Rhodium
Homogeneous catalysis
Antitumor agents
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
 
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Created: Fri, 20 Nov 2015, 23:35:33 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences