Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects

Colditz, Michael J., van Leyen, Karin and Jeffree, Rosalind L. (2012) Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects. Journal of Clinical Neuroscience, 19 12: 1611-1616. doi:10.1016/j.jocn.2012.03.013


Author Colditz, Michael J.
van Leyen, Karin
Jeffree, Rosalind L.
Title Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: Theoretical, biochemical and practical aspects
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2012-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jocn.2012.03.013
Open Access Status Not Open Access
Volume 19
Issue 12
Start page 1611
End page 1616
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Abstract The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade. This review continues from Part 1 and focuses on the biochemical mechanisms by which ALA ingestion leads to tumour fluorescence, and discusses practicalities of the equipment and techniques needed to introduce ALA and fluorescence guided resection into neurosurgical practice.
Keyword Aminolevulinic acid (ALA)
Fluorescence guided resection
Glioma
Protoporphyrin IX
Gliolan
Induced Photodynamic Therapy
Malignant Brain-Tumors
5-Aminolevulinic Acid
Protoporphyrin-IX
Glioblastoma-Multiforme
Porphyrin Fluorescence
Barretts-Esophagus
Cancer Cells
Gliomas
Surgery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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