Stem-cell-based therapy in the field of urology: A review of stem cell basic science, clinical applications and future directions in the treatment of various sexual and urinary conditions

Chung, Eric (2015) Stem-cell-based therapy in the field of urology: A review of stem cell basic science, clinical applications and future directions in the treatment of various sexual and urinary conditions. Expert Opinion on Biological Therapy, 15 11: 1623-1632. doi:10.1517/14712598.2015.1075504


Author Chung, Eric
Title Stem-cell-based therapy in the field of urology: A review of stem cell basic science, clinical applications and future directions in the treatment of various sexual and urinary conditions
Journal name Expert Opinion on Biological Therapy   Check publisher's open access policy
ISSN 1744-7682
1471-2598
Publication date 2015-11-02
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14712598.2015.1075504
Open Access Status Not yet assessed
Volume 15
Issue 11
Start page 1623
End page 1632
Total pages 10
Place of publication Oxfordshire, United Kingdom
Publisher Taylor & Francis
Language eng
Subject 3004 Pharmacology
3002 Drug Discovery
1308 Clinical Biochemistry
Abstract Introduction: Stem cell (SC) research plays a key role in the increasingly promising area of regenerative medicine, with the potential to treat, prevent and cure disease. The following article provides an overview of the basic science and brief summary of major preclinical animal studies and clinical studies pertaining to SC-based research in the field of urology. Areas covered: A literature review was conducted based on MEDLINE/PubMed searches for English articles using a combination of the following keywords: SC, SC-based therapy (SCT), urology, erectile dysfunction, Peyronie's disease (PD), bladder dysfunction, urinary incontinence, regeneration technology, tissue engineering, prostate disease and urinary bladder. Expert opinion: While current evidence is accruing to suggest that SCT showed great promise in animal studies such as in erectile dysfunction, PD and urothelial tissue engineering, and is likely to be effective and has minimal adverse effects as observed in stress urinary incontinence and bladder dysfunction, there are still significant challenges to overcome before wide spread human application. Important issues, such as reliable outcomes, safety risks with genomic or epigenetic changes in the longer term, as well as potential immune reactions and infection risks, need to be identified in more stringent clinical trials.
Formatted abstract
Introduction: Stem cell (SC) research plays a key role in the increasingly promising area of regenerative medicine, with the potential to treat, prevent and cure disease. The following article provides an overview of the basic science and brief summary of major preclinical animal studies and clinical studies pertaining to SC-based research in the field of urology.

Areas covered: A literature review was conducted based on MEDLINE/PubMed searches for English articles using a combination of the following keywords: SC, SC-based therapy (SCT), urology, erectile dysfunction, Peyronie’s disease (PD), bladder dysfunction, urinary incontinence, regeneration technology, tissue engineering, prostate disease and urinary bladder.

Expert opinion: While current evidence is accruing to suggest that SCT showed great promise in animal studies such as in erectile dysfunction, PD and urothelial tissue engineering, and is likely to be effective and has minimal adverse effects as observed in stress urinary incontinence and bladder dysfunction, there are still significant challenges to overcome before wide spread human application. Important issues, such as reliable outcomes, safety risks with genomic or epigenetic changes in the longer term, as well as potential immune reactions and infection risks, need to be identified in more stringent clinical trials.
Keyword Bladder dysfunction
Erectile dysfunction
Peyronie's disease
Stem cell
Tissue engineering
Urinary incontinence
Urology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Medicine Publications
 
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