Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course

Marioni, Riccardo E., Campbell, Archie, Scotland, Generation, Hayward, Caroline, Porteous, David J. and Deary, Ian J. (2015) Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course. European Journal of Human Genetics, 24 6: 919-923. doi:10.1038/ejhg.2015.210

Author Marioni, Riccardo E.
Campbell, Archie
Scotland, Generation
Hayward, Caroline
Porteous, David J.
Deary, Ian J.
Title Differential effects of the APOE e4 allele on different domains of cognitive ability across the life-course
Journal name European Journal of Human Genetics   Check publisher's open access policy
ISSN 1018-4813
Publication date 2015-09-23
Year available 2015
Sub-type Article (original research)
DOI 10.1038/ejhg.2015.210
Open Access Status DOI
Volume 24
Issue 6
Start page 919
End page 923
Total pages 5
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
The association between APOE genotype and cognitive function suggests a positive role for the e2 allele and a negative role for the e4 allele. Both alleles have relatively low frequencies in the general population; hence, meta-analyses have been based on many small, heterogeneous studies. Here, we report the APOE-cognition associations in the largest single analysis to date. APOE status and cognitive ability were measured in 18 337 participants from the Generation Scotland study between 2006 and 2011. The age range was 18–94 years with a mean of 47 (SD 15). Four cognitive domains were assessed: verbal declarative memory (paragraph recall), processing speed (digit symbol substitution), verbal fluency (phonemic verbal fluency), and vocabulary (Mill Hill synonyms). Linear regression was used to assess the associations between APOE genetic status and cognition. Possession of the e4 allele was associated with lower scores on the measures of memory and processing speed in subjects aged >60. Across all age ranges, the e4 allele was linked to better verbal fluency scores. In younger subjects (≤60 years) the e4 allele was linked to higher vocabulary scores. There were no associations between the e2 allele and cognitive ability. As seen in previous meta-analyses, the APOE e4 allele is linked to poorer cognitive performance in the domains of memory and processing speed. By contrast, positive associations were seen between the e4 allele and measures of verbal fluency and vocabulary. All associations were relatively small and, in many cases, nominally significant despite the very large sample size.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 11 Nov 2015, 20:27:11 EST by Susan Day on behalf of Queensland Brain Institute