3T MRI evaluation of large nerve perineural spread of head and neck cancers

Baulch, Justin, Gandhi, Mitesh, Sommerville, Jennifer and Panizza, Ben (2015) 3T MRI evaluation of large nerve perineural spread of head and neck cancers. Journal of Medical Imaging and Radiation Oncology, 59 5: 578-585. doi:10.1111/1754-9485.12338


Author Baulch, Justin
Gandhi, Mitesh
Sommerville, Jennifer
Panizza, Ben
Title 3T MRI evaluation of large nerve perineural spread of head and neck cancers
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9485
1754-9477
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/1754-9485.12338
Open Access Status Not yet assessed
Volume 59
Issue 5
Start page 578
End page 585
Total pages 8
Place of publication Richmond, Victoria, Australia
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Introduction
Accurate definition of the presence and extent of large nerve perineural spread (PNS) is a vital component in planning appropriate surgery and radiotherapy for head and neck cancers. Our research aimed to define the sensitivity and specificity of 3T MRI in detecting the presence and extent of large nerve PNS, compared with histologic evaluation.

Methods
Retrospective review of surgically proven cases of large nerve PNS in patients with preoperative 3T MRI performed as high resolution neurogram.

Results
3T MRI had a sensitivity of 95% and a specificity of 84%, detecting PNS in 36 of 38 nerves and correctly identifying uninvolved nerves in 16 of 19 cases. It correctly identified the zonal extent of spread in 32 of 36 cases (89%), underestimating the extent in three cases and overestimating the extent in one case.

Conclusion
Targeted 3T MRI is highly accurate in defining the presence and extent of large nerve PNS in head and neck cancers. However, there is still a tendency to undercall the zonal extent due to microscopic, radiologically occult involvement. Superficial large nerve involvement also remains a difficult area of detection for radiologists and should be included as a ‘check area’ for review. Further research is required to define the role radiation-induced neuritis plays in the presence of false-positive PNS on MRI.
Keyword 3T MRI
diagnosis
head and neck cancer
perineural spread
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 01 Nov 2015, 10:26:21 EST by System User on behalf of Scholarly Communication and Digitisation Service