Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide

Strittmatter, Axel W., Liesegang, Heiko, Rabus, Ralf, Decker, Iwona, Amann, Judith, Andres, Soenke, Henne, Anke, Fricke, Wolfgang Florian, Martinez-Arias, Rosa, Bartels, Daniela, Goesmann, Alexander, Krause, Lutz, Puehler, Alfred, Klenk, Hans-Peter, Richter, Michael, Schueler, Margarete, Gloeckner, Frank Oliver, Meyerdierks, Anke, Gottschalk, Gerhard and Amann, Rudolf (2009) Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide. Environmental Microbiology, 11 5: 1038-1055. doi:10.1111/j.1462-2920.2008.01825.x

Author Strittmatter, Axel W.
Liesegang, Heiko
Rabus, Ralf
Decker, Iwona
Amann, Judith
Andres, Soenke
Henne, Anke
Fricke, Wolfgang Florian
Martinez-Arias, Rosa
Bartels, Daniela
Goesmann, Alexander
Krause, Lutz
Puehler, Alfred
Klenk, Hans-Peter
Richter, Michael
Schueler, Margarete
Gloeckner, Frank Oliver
Meyerdierks, Anke
Gottschalk, Gerhard
Amann, Rudolf
Title Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide
Journal name Environmental Microbiology   Check publisher's open access policy
ISSN 1462-2912
Publication date 2009-05-01
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1462-2920.2008.01825.x
Open Access Status Not Open Access
Volume 11
Issue 5
Start page 1038
End page 1055
Total pages 18
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Sulfate-reducing bacteria (SRB) belonging to the metabolically versatile Desulfobacteriaceae are abundant in marine sediments and contribute to the global carbon cycle by complete oxidation of organic compounds. Desulfobacterium autotrophicum HRM2 is the first member of this ecophysiologically important group with a now available genome sequence. With 5.6 megabasepairs (Mbp) the genome of Db. autotrophicum HRM2 is about 2 Mbp larger than the sequenced genomes of other sulfate reducers (SRB). A high number of genome plasticity elements (> 100 transposon-related genes), several regions of GC discontinuity and a high number of repetitive elements (132 paralogous genes Mbp-1) point to a different genome evolution when comparing with Desulfovibrio spp. The metabolic versatility of Db. autotrophicum HRM2 is reflected in the presence of genes for the degradation of a variety of organic compounds including long-chain fatty acids and for the Wood-Ljungdahl pathway, which enables the organism to completely oxidize acetyl-CoA to CO2 but also to grow chemolithoautotrophically. The presence of more than 250 proteins of the sensory/regulatory protein families should enable Db. autotrophicum HRM2 to efficiently adapt to changing environmental conditions. Genes encoding periplasmic or cytoplasmic hydrogenases and formate dehydrogenases have been detected as well as genes for the transmembrane TpII-c3, Hme and Rnf complexes. Genes for subunits A, B, C and D as well as for the proposed novel subunits L and F of the heterodisulfide reductases are present. This enzyme is involved in energy conservation in methanoarchaea and it is speculated that it exhibits a similar function in the process of dissimilatory sulfate reduction in Db. autotrophicum HRM2.
Keyword Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
School of Chemistry and Molecular Biosciences
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