Complete genome sequence of the myxobacterium Sorangium cellulosum

Schneiker, Susanne, Perlova, Olena, Kaiser, Olaf, Gerth, Klaus, Alici, Aysel, Altmeyer, Matthias O., Bartels, Daniela, Bekel, Thomas, Beyer, Stefan, Bode, Edna, Bode, Helge B., Bolten, Christoph J., Choudhuri, Jomuna V., Doss, Sabrina, Elnakady, Yasser A., Frank, Bettina, Gaigalat, Lars, Goesmann, Alexander, Groeger, Carolin, Gross, Frank, Jelsbak, Lars, Jelsbak, Lotte, Kalinowski, Joern, Kegler, Carsten, Knauber, Tina, Konietzny, Sebastian, Kopp, Maren, Krause, Lutz, Krug, Daniel, Linke, Bukhard, Mahmud, Taifo, Martinez-Arias, Rosa, McHardy, Alice C., Merai, Michelle, Meyer, Folker, Mormann, Sascha, Munoz-Dorado, Jose, Perez, Juana, Pradella, Silke, Rachid, Shwan, Raddatz, Guenter, Rosenau, Frank, Rueckert, Christian, Sasse, Florenz, Scharfe, Maren, Schuster, Stephan C., Suen, Garret, Treuner-Lange, Anke, Velicer, Gregory J., Vorhoelter, Frank-Joerg, Weissman, Kira J., Welch, Roy D., Wenzel, Silke C., Whitworth, David E., Wilhelm, Susanne, Wittmann, Christoph, Bloecker, Helmut, Puehler, Alfred and Mueller, Rolf (2007) Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25 11: 1281-1289. doi:10.1038/nbt1354

Author Schneiker, Susanne
Perlova, Olena
Kaiser, Olaf
Gerth, Klaus
Alici, Aysel
Altmeyer, Matthias O.
Bartels, Daniela
Bekel, Thomas
Beyer, Stefan
Bode, Edna
Bode, Helge B.
Bolten, Christoph J.
Choudhuri, Jomuna V.
Doss, Sabrina
Elnakady, Yasser A.
Frank, Bettina
Gaigalat, Lars
Goesmann, Alexander
Groeger, Carolin
Gross, Frank
Jelsbak, Lars
Jelsbak, Lotte
Kalinowski, Joern
Kegler, Carsten
Knauber, Tina
Konietzny, Sebastian
Kopp, Maren
Krause, Lutz
Krug, Daniel
Linke, Bukhard
Mahmud, Taifo
Martinez-Arias, Rosa
McHardy, Alice C.
Merai, Michelle
Meyer, Folker
Mormann, Sascha
Munoz-Dorado, Jose
Perez, Juana
Pradella, Silke
Rachid, Shwan
Raddatz, Guenter
Rosenau, Frank
Rueckert, Christian
Sasse, Florenz
Scharfe, Maren
Schuster, Stephan C.
Suen, Garret
Treuner-Lange, Anke
Velicer, Gregory J.
Vorhoelter, Frank-Joerg
Weissman, Kira J.
Welch, Roy D.
Wenzel, Silke C.
Whitworth, David E.
Wilhelm, Susanne
Wittmann, Christoph
Bloecker, Helmut
Puehler, Alfred
Mueller, Rolf
Title Complete genome sequence of the myxobacterium Sorangium cellulosum
Formatted title
Complete genome sequence of the myxobacterium Sorangium cellulosum
Journal name Nature Biotechnology   Check publisher's open access policy
ISSN 1087-0156
Publication date 2007-11-01
Year available 2007
Sub-type Article (original research)
DOI 10.1038/nbt1354
Open Access Status Not yet assessed
Volume 25
Issue 11
Start page 1281
End page 1289
Total pages 9
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.
Keyword Biotechnology & Applied Microbiology
Biotechnology & Applied Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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