The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial

Devin, James L., Sax, Andrew T., Hughes, Gareth I., Jenkins, David G., Aitken, Joanne F., Chambers, Suzanne K., Dunn, Jeffrey C., Bolam, Kate A. and Skinner, Tina L. (2016) The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial. Journal of Cancer Survivorship, 10 3: 467-479. doi:10.1007/s11764-015-0490-7


Author Devin, James L.
Sax, Andrew T.
Hughes, Gareth I.
Jenkins, David G.
Aitken, Joanne F.
Chambers, Suzanne K.
Dunn, Jeffrey C.
Bolam, Kate A.
Skinner, Tina L.
Title The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial
Journal name Journal of Cancer Survivorship   Check publisher's open access policy
ISSN 1932-2259
1932-2267
Publication date 2016-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1007/s11764-015-0490-7
Open Access Status Not Open Access
Volume 10
Issue 3
Start page 467
End page 479
Total pages 13
Place of publication New York, United States
Publisher Springer
Language eng
Abstract Following colorectal cancer diagnosis and anti-cancer therapy, declines in cardiorespiratory fitness and body composition lead to significant increases in morbidity and mortality. There is increasing interest within the field of exercise oncology surrounding potential strategies to remediate these adverse outcomes. This study compared 4 weeks of moderate-intensity exercise (MIE) and high-intensity exercise (HIE) training on peak oxygen consumption (VI double dagger O(2)peak) and body composition in colorectal cancer survivors.
Formatted abstract
Purpose
Following colorectal cancer diagnosis and anti-cancer therapy, declines in cardiorespiratory fitness and body composition lead to significant increases in morbidity and mortality. There is increasing interest within the field of exercise oncology surrounding potential strategies to remediate these adverse outcomes. This study compared 4 weeks of moderate-intensity exercise (MIE) and high-intensity exercise (HIE) training on peak oxygen consumption (V̇O2peak) and body composition in colorectal cancer survivors.

Methods

Forty seven post-treatment colorectal cancer survivors (HIE = 27 months post-treatment; MIE = 38 months post-treatment) were randomised to either HIE [85–95 % peak heart rate (HRpeak)] or MIE (70 % HRpeak) in equivalence with current physical activity guidelines and completed 12 training sessions over 4 weeks.

Results

HIE was superior to MIE in improving absolute (p = 0.016) and relative (p = 0.021) V̇O2peak. Absolute (+0.28 L.min−1, p < 0.001) and relative (+3.5 ml.kg−1.min−1, p < 0.001) V̇O2 peak were increased in the HIE group but not the MIE group following training. HIE led to significant increases in lean mass (+0.72 kg, p = 0.002) and decreases in fat mass (−0.74 kg, p < 0.001) and fat percentage (−1.0 %, p < 0.001), whereas no changes were observed for the MIE group. There were no severe adverse events.

Conclusions

In response to short-term training, HIE is a safe, feasible and efficacious intervention that offers clinically meaningful improvements in cardiorespiratory fitness and body composition for colorectal cancer survivors.
Implications for Cancer Survivors
HIE appears to offer superior improvements in cardiorespiratory fitness and body composition in comparison to current physical activity recommendations for colorectal cancer survivors and therefore may be an effective clinical utility following treatment.
Keyword Colorectal cancer
Exercise
Exercise oncology
High intensity exercise
Cardiorespiratory fitness
Body composition
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2013001802
Institutional Status UQ
Additional Notes Published online 19 October 2015

 
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Created: Fri, 23 Oct 2015, 00:02:07 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences