Modelling wound closure in an epithelial cell sheet using the cellular Potts model

Noppe, Adrian R., Roberts, Anthony P., Yap, Alpha S., Gomez, Guillermo A. and Neufeld, Zoltan (2015) Modelling wound closure in an epithelial cell sheet using the cellular Potts model. Integrative Biology (United Kingdom), 7 10: 1253-1264. doi:10.1039/c5ib00053j

Author Noppe, Adrian R.
Roberts, Anthony P.
Yap, Alpha S.
Gomez, Guillermo A.
Neufeld, Zoltan
Title Modelling wound closure in an epithelial cell sheet using the cellular Potts model
Journal name Integrative Biology (United Kingdom)   Check publisher's open access policy
ISSN 1757-9708
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1039/c5ib00053j
Open Access Status Not Open Access
Volume 7
Issue 10
Start page 1253
End page 1264
Total pages 12
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Subject 1304 Biophysics
1303 Biochemistry
Abstract We use a two-dimensional cellular Potts model to represent the behavior of an epithelial cell layer and describe its dynamics in response to a microscopic wound. Using an energy function to describe properties of the cells, we found that the interaction between contractile tension along cell–cell junctions and cell–cell adhesion plays an important role not only in determining the dynamics and morphology of cells in the monolayer, but also in influencing whether or not a wound in the monolayer will close. Our results suggest that, depending on the balance between cell–cell adhesion and junctional tension, mechanics of the monolayer can either correspond to a hard or a soft regime that determines cell morphology and polygonal organization in the monolayer. Moreover, the presence of a wound in a hard regime, where junctional tension is significant, can lead to two results: (1) wound closure or (2) an initial increase and expansion of the wound area towards an equilibrium value. Theoretical approximations and simulations allowed us to determine the thresholds in the values of cell–cell adhesion and initial wound size that allow the system to lead to wound closure. Overall, our results suggest that around the site of injury, changes in the balance between contraction and adhesion determine whether or not non-monotonous wound closure occurs.
Keyword Cell Biology
Cell Biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1044041
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2016 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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