Cancers in Australia in 2010 attributable to infectious agents

Antonsson, Annika, Wilson, Louise F., Kendall, Bradley J., Bain, Christopher J., Whiteman, David C. and Neale, Rachel E. (2015) Cancers in Australia in 2010 attributable to infectious agents. Australian and New Zealand Journal of Public Health, 39 5: 446-451. doi:10.1111/1753-6405.12445


Author Antonsson, Annika
Wilson, Louise F.
Kendall, Bradley J.
Bain, Christopher J.
Whiteman, David C.
Neale, Rachel E.
Title Cancers in Australia in 2010 attributable to infectious agents
Journal name Australian and New Zealand Journal of Public Health   Check publisher's open access policy
ISSN 1753-6405
1326-0200
Publication date 2015-10-01
Year available 2015
Sub-type Article (original research)
DOI 10.1111/1753-6405.12445
Open Access Status DOI
Volume 39
Issue 5
Start page 446
End page 451
Total pages 6
Place of publication Richmond, Victoria, Australia
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objectives: To estimate the proportion and numbers of cancers in Australia in 2010 attributable to infectious agents.

Methods: The population attributable fraction (PAF) and number of cancers caused by hepatitis B and C viruses (HBV, HCV), Helicobacter pylori and human immunodeficiency virus (HIV) were calculated using standard formulae incorporating prevalence of infection in the Australian population, the relative risks associated with that infection and cancer incidence. For cancers with very strong associations to the infectious agent (Epstein-Barr virus [EBV], human papillomavirus [HPV] and HIV/Kaposi's sarcoma herpes virus [KSHV]), calculations were based on viral prevalence in the tumour.

Results: An estimated 3,421 cancers (2.9% of all cancers) in Australia in 2010 were attributable to infections. Infectious agents causing the largest numbers of cancers were HPV (n=1,706), H. pylori (n=793) and HBV/HCV (n=518). Cancer sites with the greatest number of cancers caused by infections were cervix (n=818), stomach (n=694) and liver (n=483). Cancers with highest proportions attributable to infectious agents were Kaposi's sarcoma (100%), cervix (100%), nasopharynx (87%), anus (84%) and vagina (70%).

Conclusions: Infectious agents cause more than 3,000 cancers annually in Australia.
Keyword population attributable fraction
cancer
risk factor
infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
School of Medicine Publications
 
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