Genes influence the amplitude and timing of brain hemodynamic responses

Shan, Zuyao Y., Vinkhuyzen, Anna A. E., Thompson, Paul M., McMahon, Katie L., Blokland, Gabriella A.M., de Zubicaray, Greig I., Calhoun, Vince, Martin, Nicholas G., Visscher, Peter M., Wright, Margaret J. and Reutens, David C. (2016) Genes influence the amplitude and timing of brain hemodynamic responses. NeuroImage, 124 Part A: 663-671. doi:10.1016/j.neuroimage.2015.09.016

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Author Shan, Zuyao Y.
Vinkhuyzen, Anna A. E.
Thompson, Paul M.
McMahon, Katie L.
Blokland, Gabriella A.M.
de Zubicaray, Greig I.
Calhoun, Vince
Martin, Nicholas G.
Visscher, Peter M.
Wright, Margaret J.
Reutens, David C.
Title Genes influence the amplitude and timing of brain hemodynamic responses
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2016-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2015.09.016
Open Access Status File (Author Post-print)
Volume 124
Issue Part A
Start page 663
End page 671
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Subject 2808 Neurology
2805 Cognitive Neuroscience
Abstract In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology. (C) 2015 Elsevier Inc. All rights reserved.
Formatted abstract
In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%–51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.
Keyword Hemodynamic response function (HRF)
Heritability
Neurovascular coupling
Twin study
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID RO1 HD050735
496682 | 1009064 | 628952
Institutional Status UQ
Additional Notes Published online 12 September 2015

 
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