Dendritic organization of olfactory inputs to medial amygdala neurons

Keshavarzi, Sepideh, Power, John M., Albers, Eva H.H., Sullivan, Robert K.S. and Sah, Pankaj (2015) Dendritic organization of olfactory inputs to medial amygdala neurons. Journal of Neuroscience, 35 38: 13020-13028. doi:10.1523/JNEUROSCI.0627-15.2015

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Author Keshavarzi, Sepideh
Power, John M.
Albers, Eva H.H.
Sullivan, Robert K.S.
Sah, Pankaj
Title Dendritic organization of olfactory inputs to medial amygdala neurons
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 1529-2401
Publication date 2015-09-23
Year available 2015
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.0627-15.2015
Open Access Status File (Publisher version)
Volume 35
Issue 38
Start page 13020
End page 13028
Total pages 9
Place of publication Washington, United States
Publisher Society for Neuroscience
Language eng
Formatted abstract
The medial amygdala (MeA) is a central hub in the olfactory neural network. It receives vomeronasal information directly from the accessory olfactory bulb (AOB) and main olfactory information largely via odor-processing regions such as the olfactory cortical amygdala (CoA). How these inputs are processed by MeA neurons is poorly understood. Using the GAD67-GFP mouse, we show that MeA principal neurons receive convergent AOB and CoA inputs. Somatically recorded AOB synaptic inputs had slower kinetics than CoA inputs, suggesting that they are electrotonically more distant. Field potential recording, pharmacological manipulation, and Ca2+ imaging revealed that AOB synapses are confined to distal dendrites and segregated from the proximally located CoA synapses. Moreover, unsynchronized AOB inputs had significantly broader temporal summation that was dependent on the activation of NMDA receptors. These findings show that MeA principal neurons process main and accessory olfactory inputs differentially in distinct dendritic compartments.
Keyword Dendrite
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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