The Role of FDG-PET in the Diagnosis and Staging of Ocular Adnexal Lymphoproliferative Disease

English, James F. and Sullivan, Timothy J. (2015) The Role of FDG-PET in the Diagnosis and Staging of Ocular Adnexal Lymphoproliferative Disease. Orbit, 34 5: 284-291. doi:10.3109/01676830.2015.1078368

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Author English, James F.
Sullivan, Timothy J.
Title The Role of FDG-PET in the Diagnosis and Staging of Ocular Adnexal Lymphoproliferative Disease
Journal name Orbit   Check publisher's open access policy
ISSN 0167-6830
Publication date 2015-01-01
Year available 2015
Sub-type Article (original research)
DOI 10.3109/01676830.2015.1078368
Open Access Status Not Open Access
Volume 34
Issue 5
Start page 284
End page 291
Total pages 8
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor and Francis
Language eng
Formatted abstract
Purpose: To further evaluate fluorine 18 fluoro-deoxyglucose positron emission tomography (FDG PET) in the staging of ocular adnexal lymphoproliferative disease (OALD).

Methods: Retrospective and prospective case series with review of clinical and imaging records including computed tomography (CT), FDG PET (±PET/CT) and/or magnetic resonance imaging (MRI).

Results: Thirty-four patients had FDG PET and CT scans at initial staging. Eleven were retrospectively reviewed and 23 were prospectively enrolled. Of 34 patients, 17 (50%) had primary disease, 17 (50%) had secondary and of these, 13 patients (38%) had OALD as their initial manifestation. Sixteen patients had active systemic disease in conjunction with their orbital disease. Systemic disease was demonstrated by FDG PET (± CT) in 15 of 16 (94%) patients and 11 of 16 (69%) patients with CT. FDG PET found orbital disease in 27 of 34 patients (79%) versus 33 of 34 patients with orbital CT (97%). Four of 16 patients in which FDG-PET detected systemic disease where CT did not were upstaged and their management changed significantly in 5 cases.

Conclusions: This study reaffirms FDG PET as an important part of initial staging. Our study suggests FDG PET detects systemic disease more reliably than CT alone and results in significant changes in management. Our findings suggest FDG PET detection for local OALD is less sensitive than CT. MRI is helpful in augmenting other imaging modalities in further identifying disease. Given the prevalence of simultaneous systemic presentations of OALD, FDG PET in this regard is especially important and highlights the need for coordinated multidisciplinary care.
Keyword Adnexal
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Medicine Publications
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Created: Tue, 06 Oct 2015, 12:28:35 EST by System User on behalf of Medicine - Royal Brisbane and Women's Hospital