Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro

Faber, ESL, Callister, RJ and Sah, P (2001) Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro. Journal of Neurophysiology, 85 2: 714-723.

Author Faber, ESL
Callister, RJ
Sah, P
Title Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro
Journal name Journal of Neurophysiology   Check publisher's open access policy
ISSN 0022-3077
Publication date 2001-01-01
Sub-type Article (original research)
Volume 85
Issue 2
Start page 714
End page 723
Total pages 10
Place of publication Bethesda
Publisher Amer Physiological Soc
Language eng
Abstract In this study, we characterize the electrophysiological and morphological properties of spiny principal neurons in the rat lateral amygdala using whole cell recordings in acute brain slices. These neurons exhibited a range of firing properties in response to prolonged current injection. Responses varied from cells that showed full spike frequency adaptation, spiking three to five times, to those that showed no adaptation. The differences in firing patterns were largely explained by the amplitude of the afterhyperpolarization (AHP) that followed spike trains. Cells that showed full spike frequency adaptation had large amplitude slow AHPs, whereas cells that discharged tonically had slow AHPs of much smaller amplitude. During spike trains, all cells showed a similar broadening of their action potentials. Biocytin-filled neurons showed a range of pyramidal-like morphologies, differed in dendritic complexity, had spiny dendrites, and differed in the degree to which they clearly exhibited apical versus basal dendrites. Quantitative analysis revealed no association between cell morphology and firing properties. We conclude that the discharge properties of neurons in the lateral nucleus, in response to somatic current injections, are determined by the differential distribution of ionic conductances rather than through mechanisms that rely on cell morphology.
Keyword Neurosciences
Physiology
Ca1 Pyramidal Neurons
Basolateral Amygdala
Projection Neurons
Firing Patterns
Visual-cortex
In-vivo
Nucleus
Interneurons
Emotion
Complex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 13 Aug 2007, 22:10:55 EST