Sensory deviancy detection measured directly within the human nucleus accumbens

Dürschmid, Stefan, Zaehle, Tino, Hinrichs, Hermann, Heinze, Hans-Jochen, Voges, Jürgen, Garrido, Marta I., Dolan, Raymond J. and Knight, Robert T. (2015) Sensory deviancy detection measured directly within the human nucleus accumbens. Cerebral Cortex, 26 3: 1168-1175. doi:10.1093/cercor/bhu304

Author Dürschmid, Stefan
Zaehle, Tino
Hinrichs, Hermann
Heinze, Hans-Jochen
Voges, Jürgen
Garrido, Marta I.
Dolan, Raymond J.
Knight, Robert T.
Title Sensory deviancy detection measured directly within the human nucleus accumbens
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.1093/cercor/bhu304
Open Access Status Not Open Access
Volume 26
Issue 3
Start page 1168
End page 1175
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2805 Cognitive Neuroscience
2804 Cellular and Molecular Neuroscience
Abstract Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.
Keyword P3
auditory mismatch
nucleus accumbens
prediction error
predictive coding
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 098362
R37 NS021135
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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Created: Tue, 29 Sep 2015, 22:25:37 EST by Lorine Wilkinson on behalf of Centre for Advanced Imaging