Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: Systematic review and meta-analysis of randomized controlled trials

Kotirum, Surachai, Ismail, Shaiful Bahari and Chaiyakunapruk, Nathorn (2015) Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: Systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 23 5: 693-698. doi:10.1016/j.ctim.2015.07.009

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Author Kotirum, Surachai
Ismail, Shaiful Bahari
Chaiyakunapruk, Nathorn
Title Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: Systematic review and meta-analysis of randomized controlled trials
Journal name Complementary Therapies in Medicine   Check publisher's open access policy
ISSN 1873-6963
0965-2299
Publication date 2015-10-01
Sub-type Article (original research)
DOI 10.1016/j.ctim.2015.07.009
Open Access Status File (Author Post-print)
Volume 23
Issue 5
Start page 693
End page 698
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Subject 3603 Complementary and Manual Therapy
2707 Complementary and alternative medicine
2902 Advanced and Specialised Nursing
Abstract Objective: To determine the efficacy of Tongkat Ali (Eurycoma longifolia) herbal extract on erectile function improvement. Methods: Comprehensive electronic databases were searched from inception through October 2014. Randomized controlled trials investigating Tongkat Ali compared to placebo were included. Outcome of interest was the improvement of erectile dysfunction. The difference of changes from baseline of the outcome between Tongkat Ali and placebo was pooled using weighted mean difference (WMD). Methodological quality of included studies was assessed using Jadad's quality scale and Cochrane's risk of bias. Results: Of the 342 articles identified, 2 studies involving a total of 139 participants were analyzed. No significance between group difference was found in the mean WMD of the change in the 5- item version of the international index of erectile function (IIEF-5) at week-12 (0.91; 95% CI: -1.50 to 3.33 with I2=89.5%, P-value=0.002) with statistical heterogeneity. Based on the subgroup analysis, significant improved IIEF-5 score of 2.15 (95% CI 1.03-3.27) was found in subjects with lower baseline IIEF-5 score, but this was not seen among those with higher baseline IIEF-5 score. Conclusion: Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function. However, more efficacy trials are warranted to further support current evidence.
Formatted abstract
Objective: To determine the efficacy of Tongkat Ali (Eurycoma longifolia) herbal extract on erectile function improvement.

Methods: Comprehensive electronic databases were searched from inception through October 2014. Randomized controlled trials investigating Tongkat Ali compared to placebo were included. Outcome of interest was the improvement of erectile dysfunction. The difference of changes from baseline of the outcome between Tongkat Ali and placebo was pooled using weighted mean difference (WMD). Methodological quality of included studies was assessed using Jadad’s quality scale and Cochrane’s risk of bias.

Results: Of the 342 articles identified, 2 studies involving a total of 139 participants were analyzed. No significance between group difference was found in the mean WMD of the change in the 5- item version of the international index of erectile function (IIEF-5) at week-12 (0.91; 95% CI: −1.50 to 3.33 with I2 = 89.5%, P-value = 0.002) with statistical heterogeneity. Based on the subgroup analysis, significant improved IIEF-5 score of 2.15 (95% CI 1.03–3.27) was found in subjects with lower baseline IIEF-5 score, but this was not seen among those with higher baseline IIEF-5 score.

Conclusion: Based on current evidence, the herbal extract of Tongkat Ali may have clinical effect on erectile function. However, more efficacy trials are warranted to further support current evidence.
Keyword Alternative medicine
Erectile dysfunction
Eurycoma longifolia
Extract
Root
Tongkat ali
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Public Health Publications
 
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