Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

Li, Hongmei, Bapat, Abhijeet P., Li, Ming and Sumerlin, Brent S. (2011) Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT. Polymer Chemistry, 2 2: 323-327. doi:10.1039/c0py00178c


Author Li, Hongmei
Bapat, Abhijeet P.
Li, Ming
Sumerlin, Brent S.
Title Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT
Journal name Polymer Chemistry   Check publisher's open access policy
ISSN 1759-9954
1759-9962
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1039/c0py00178c
Open Access Status Not yet assessed
Volume 2
Issue 2
Start page 323
End page 327
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract Reversible addition-fragmentation chain transfer (RAFT) of N-isopropylacrylamide with a chain transfer agent containing an activated-ester moiety was employed to prepare well-defined temperature-responsive polymers for conjugation to amine-containing proteins. Bioconjugation efficiency of the polymers with lysozyme was investigated as a function of stoichiometry, polymer molecular weight, and reaction pH. The resulting polymer-protein conjugates retained the temperature-responsive nature of the original polymers.
Keyword Polymer Science
Polymer Science
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Sun, 27 Sep 2015, 23:46:30 EST by Abhijeet Bapat on behalf of Aust Institute for Bioengineering & Nanotechnology