Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis

Street, Shayna E. A., Cretney, Erika and Smyth, Mark J. (2001) Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood, 97 1: 192-197. doi:10.1182/blood.V97.1.192


Author Street, Shayna E. A.
Cretney, Erika
Smyth, Mark J.
Title Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
1528-0020
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1182/blood.V97.1.192
Open Access Status DOI
Volume 97
Issue 1
Start page 192
End page 197
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society of Hematology
Language eng
Abstract Perforin (pfp) and interferon-gamma (IFN-gamma) together in C57BL/6 (B6) and BALB/c mouse strains provided optimal protection in 3 separate tumor models controlled by innate immunity. Using experimental (B6, RM-1 prostate carcinoma) and spontaneous (BALB/c, DA3 mammary carcinoma) models of metastatic cancer, mice deficient in both pfp and IFN-gamma were significantly less proficient than pfp- or IFN-gamma -deficient mice in preventing metastasis of tumor cells to the lung. Pfp and IFN-gamma -deficient mice were as susceptible as mice depleted of natural killer (NK) cells in both tumor metastasis models, and IFN-gamma appeared to play an early role in protection from metastasis, Previous experiments in a model of fibrosarcoma induced by the chemical carcinogen methylcholanthrene indicated an important role for NK1.1(+) T cells, Herein, both pfp and IFN-gamma played critical and independent roles in providing the host with protection equivalent to that mediated by NK1.1+ T cells, Further analysis demonstrated that IFN-gamma, but not pfp, controlled the growth rate of sarcomas arising in these mice. Thus, this is the first study to demonstrate that host IFN-gamma, and direct cytotoxicity mediated by cytotoxic lymphocytes expressing pfp independently contribute antitumor effector functions that together control the initiation, growth, and spread of tumors in mice, (C) 2001 by The American Society of Hematology.
Keyword Hematology
Natural-killer-cells
T-cells
Deficient mice
In-vivo
Cutting edge
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Diamantina Institute - Open Access Collection
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 319 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 351 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 13 Aug 2007, 22:07:33 EST