3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene

James, MO and Little, PJ (1984) 3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene. Comparative Biochemistry and Physiology. Part C, Comparative, 78 1: 241-245. doi:10.1016/0742-8413(84)90076-8


Author James, MO
Little, PJ
Title 3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1984-01-01
Year available 1984
Sub-type Article (original research)
DOI 10.1016/0742-8413(84)90076-8
Volume 78
Issue 1
Start page 241
End page 245
Total pages 5
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 2403 Immunology
3004 Pharmacology
Abstract 1. Administration of 3-methylcholanthrene (10 mg/kg) i.m. to spiny lobsters, Panulirus argus, did not cause induction of the cytochrome P-450 content of hepatopancreas microsomes. 2. The rate of oxidation of benzo[a]pyrene or 7-ethoxyresorufin in reductase-fortified preparations of hepatopancreas microsomes was the same for corn oil-treated or 3-methylcholanthrene-treated lobsters. 3. Administration of 3-methylcholanthrene (10 mg/kg) i.m. to spiny lobsters one week prior to an i.v. dose of [14C]benzotalpyrene (1 mg/kg) did not influence the disposition of the radiolabelled benzo[a]pyrene in lobsters. 4. At one week after the dose of [14C]benzo[a]pyrene, approximately 40% of the dose of [14C]benzo[a]pyrene remained in the lobsters, regardless of treatment. 5. The digestive tract (hepatopancreas, intestinal contents, stomach and intestine) contained most (86%) of the 14C remaining in the lobsters.
Keyword Biochemistry & Molecular Biology
Endocrinology & Metabolism
Toxicology
Zoology
Biochemistry & Molecular Biology
Endocrinology & Metabolism
Toxicology
Zoology
BIOCHEMISTRY & MOLECULAR BIOLOGY
ENDOCRINOLOGY & METABOLISM
TOXICOLOGY
ZOOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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