Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries

Dilley, Rodney J., Farrelly, Caroline A., Allen, Terri J., Jandeleit-Dahm, Karin, Cooper, Mark E., Morahan, Grant and Little, Peter J. (2005) Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries. Diabetes Research and Clinical Practice, 70 3: 201-208. doi:10.1016/j.diabres.2005.03.038

Author Dilley, Rodney J.
Farrelly, Caroline A.
Allen, Terri J.
Jandeleit-Dahm, Karin
Cooper, Mark E.
Morahan, Grant
Little, Peter J.
Title Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries
Journal name Diabetes Research and Clinical Practice   Check publisher's open access policy
ISSN 0168-8227
Publication date 2005-12-01
Sub-type Article (original research)
DOI 10.1016/j.diabres.2005.03.038
Open Access Status Not yet assessed
Volume 70
Issue 3
Start page 201
End page 208
Total pages 8
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract Experimental hyperglycemia produces a marked hypertrophic response in rat mesenteric arteries, accompanied by activation of Na/H exchange (NHE) in medial smooth muscle. This study asked if other vascular beds are similarly affected by examining the hypertrophic and NHE response of the basilar artery. Sections of mesenteric and basilar arteries from adult rats were analysed by standard morphometric techniques at 1 and 3 weeks after streptozotocin injection. NHE activity was assessed as changes in intracellular pH in isolated intact vessels using concurrent myography and fluorescence spectroscopy. Mesenteric arteries showed a significant increase in lumenal (47%), medial (51%) and adventitial (17%) area. In contrast, these parameters were not increased in basilar arteries from the same set of animals. Maximal NHE activity was significantly increased at 1 week (24%) and 3 weeks (20%) in mesenteric arteries, but in basilar arteries there was no change in basal intracellular pH, maximal NHE activity or kinetic properties of the transporter. NHE plays a central role in vascular changes in diabetes. As the mesenteric hypertrophy is amenable to therapeutic intervention these findings add further to the potential of NHE as a therapeutic target for ameliorating vascular disease in diabetes.
Keyword Basilar arteries
Mesenteric arteries
Na/H exchanger
Vascular smooth muscle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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