Plasma noradrenaline kinetics in humans

Esler, M, Willett, I, Leonard, P, Hasking, G, Johns, J, Little, P and Jennings, G (1984) Plasma noradrenaline kinetics in humans. Journal of the Autonomic Nervous System, 11 2: 125-144. doi:10.1016/0165-1838(84)90071-7


Author Esler, M
Willett, I
Leonard, P
Hasking, G
Johns, J
Little, P
Jennings, G
Title Plasma noradrenaline kinetics in humans
Journal name Journal of the Autonomic Nervous System   Check publisher's open access policy
ISSN 0165-1838
Publication date 1984-01-01
Year available 1984
Sub-type Article (original research)
DOI 10.1016/0165-1838(84)90071-7
Volume 11
Issue 2
Start page 125
End page 144
Total pages 20
Publisher ELSEVIER SCIENCE BV
Language eng
Subject 1314 Physiology
2728 Clinical Neurology
2800 Neuroscience
Abstract Recently developed radiotracer methods for measuring the overall rate of release of noradrenaline to plasma, for the body as a whole, can be used to estimate 'total sympathetic nervous system activity' in humans. These techniques find application in clinical studies of sympathetic nervous physiology and pharmacology. The inherent weakness of any biochemical test of global sympathetic tone such as this lies in the fact that sympathetic nervous system responses typically show regional differentiation. Biochemical indices of overall sympathetic activity are insufficiently discriminating to delineate patterns of sympathetic nervous response, representing instead an algebraic sum of all regional increases or decreases in sympathetic tone. Modification of the whole-body radiotracer methodology enables organ-specific sympathetic nervous system activity to be estimated, from measurements of regional release of noradrenaline to plasma. This should facilitate investigation of possible sympathetic pathophysiology in disease states. Illustrative of potential application of the method are preliminary findings of increased renal sympathetic nervous tone in young patients with essential hypertension, and of selective activation of sympathetic nerves to the kidney by diuretics.
Keyword noradrenaline clearance
noradrenaline release
sympathetic nervous system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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