Effects of Steroid Hormones on Sex Differences in Cerebral Perfusion

Ghisleni, Carmen, Bollmann, Steffen, Biason-Lauber, Anna, Poil, Simon-Shlomo, Brandeis, Daniel, Martin, Ernst, Michels, Lars, Hersberger, Martin, Suckling, John, Klaver, Peter and O'Gorman, Ruth L. (2015) Effects of Steroid Hormones on Sex Differences in Cerebral Perfusion. PLoS One, 10 9: e0135827-e0135827. doi:10.1371/journal.pone.0135827

Author Ghisleni, Carmen
Bollmann, Steffen
Biason-Lauber, Anna
Poil, Simon-Shlomo
Brandeis, Daniel
Martin, Ernst
Michels, Lars
Hersberger, Martin
Suckling, John
Klaver, Peter
O'Gorman, Ruth L.
Title Effects of Steroid Hormones on Sex Differences in Cerebral Perfusion
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2015-09-10
Year available 2015
Sub-type Article (original research)
DOI 10.1371/journal.pone.0135827
Open Access Status DOI
Volume 10
Issue 9
Start page e0135827
End page e0135827
Total pages 15
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Formatted abstract
Sex differences in the brain appear to play an important role in the prevalence and progression of various neuropsychiatric disorders, but to date little is known about the cerebral mechanisms underlying these differences. One widely reported finding is that women demonstrate higher cerebral perfusion than men, but the underlying cause of this difference in perfusion is not known. This study investigated the putative role of steroid hormones such as oestradiol, testosterone, and dehydroepiandrosterone sulphate (DHEAS) as underlying factors influencing cerebral perfusion. We acquired arterial spin labelling perfusion images of 36 healthy adult subjects (16 men, 20 women). Analyses on average whole brain perfusion
levels included a multiple regression analysis to test for the relative impact of each hormone on the global perfusion. Additionally, voxel-based analyses were performed to investigate the sex difference in regional perfusion as well as the correlations between local perfusion and serum oestradiol, testosterone, and DHEAS concentrations. Our results replicated
the known sex difference in perfusion, with women showing significantly higher global and regional perfusion. For the global perfusion, DHEAS was the only significant predictor amongst the steroid hormones, showing a strong negative correlation with cerebral perfusion.  The voxel-based analyses revealed modest sex-dependent correlations between local perfusion and testosterone, in addition to a strong modulatory effect of DHEAS in cortical, subcortical, and cerebellar regions. We conclude that DHEAS in particular may play an important role as an underlying factor driving the difference in cerebral perfusion between men and women.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 14 Sep 2015, 20:37:16 EST by Steffen Bollmann on behalf of Centre for Advanced Imaging