The frequencies of Killer immunoglobulin-like receptors and their HLA ligands in chronic inflammatory demyelinating polyradiculoneuropathy are similar to those in Guillian Barre syndrome but differ from those of controls, suggesting a role for NK cells in

Blum, Stefan, Csurhes, Peter and McCombe, Pamela (2015) The frequencies of Killer immunoglobulin-like receptors and their HLA ligands in chronic inflammatory demyelinating polyradiculoneuropathy are similar to those in Guillian Barre syndrome but differ from those of controls, suggesting a role for NK cells in. Journal of Neuroimmunology, 285 53-56. doi:10.1016/j.jneuroim.2015.05.017


Author Blum, Stefan
Csurhes, Peter
McCombe, Pamela
Title The frequencies of Killer immunoglobulin-like receptors and their HLA ligands in chronic inflammatory demyelinating polyradiculoneuropathy are similar to those in Guillian Barre syndrome but differ from those of controls, suggesting a role for NK cells in
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
1872-8421
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2015.05.017
Open Access Status Not Open Access
Volume 285
Start page 53
End page 56
Total pages 4
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired inflammatory neuropathy, which has similar clinical and pathological features to Guillain–Barré Syndrome (GBS), but differs in time course. We investigated the frequency of genes encoding Killer immunoglobulin-like receptors and their HLA ligands in subjects with CIDP, in subjects with GBS and in healthy controls. There were no differences in KIR gene frequency among the 3 groups. The gene frequencies for HLA-B Bw4-I were significantly greater in CIDP than HC, but did not differ from GBS. The frequency of the combination of 3DL1/HLA-B Bw4I was greater in CIDP than HC, but did not differ from that of GBS. These data raise the possibility of NK cell function being an important factor in the pathogenesis of CIDP.
Keyword Killer immunoglobulin like receptors
Human leucocyte antigen
Chronic inflammatory demyelinating polyradiculoneuropathy
Guillain Barre Syndrome
NK cells
Diagnostic criteria
Polyneuropathy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2016 Collection
School of Medicine Publications
 
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