(-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor

Paz, Cristian, Becerra, Jose, Silva, Mario, Burgos, Viviana, Heydenreich, Matthias, Schmidt, Bernd, Thu Tran and Vetter, Irina (2015) (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor. Natural Product Communications, 10 8: 1355-1357.

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Name Description MIMEType Size Downloads
Author Paz, Cristian
Becerra, Jose
Silva, Mario
Burgos, Viviana
Heydenreich, Matthias
Schmidt, Bernd
Thu Tran
Vetter, Irina
Title (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor
Formatted title
(-)-Pentylsedinine, a new alkaloid from the leaves of Lobelia tupa with agonist activity at nicotinic acetylcholine receptor
Journal name Natural Product Communications   Check publisher's open access policy
ISSN 1934-578X
1555-9475
Publication date 2015-08-01
Year available 2015
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 10
Issue 8
Start page 1355
End page 1357
Total pages 3
Place of publication Westerville, OH, United States
Publisher Natural Product
Language eng
Formatted abstract
Lobelia tupa, also called devil's tobacco, is a native plant from the center-south of Chile which has been used by the native people of Chile as a hallucinogenic and anesthetic plant. A new piperidine alkaloid, called pentylsedinine, which comprises five carbons in the side chain, was isolated from the aerial part of L. tupa, along with lobeline and lobelanidine. The structure was established on the basis of 1D and 2D NMR spectroscopy. While lobeline is a neutral antagonist at α3β2/α3β4 nAChR and α7 nAChR, both lobelanidine and pentylsedinine act as partial agonists at nAChR
Keyword Lobelia tupa
Piperidine alkaloid
nAChR
Pentylsedinine
Sedum Alkaloids
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 3130378
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
Institute for Molecular Bioscience - Publications
 
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