Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Nixon, PF, Diefenbach, RJ and Duggleby, RG (1992) Inhibition of transketolase and pyruvate decarboxylase by omeprazole. Biochemical Pharmacology, 44 1: 177-179. doi:10.1016/0006-2952(92)90053-L


Author Nixon, PF
Diefenbach, RJ
Duggleby, RG
Title Inhibition of transketolase and pyruvate decarboxylase by omeprazole
Journal name Biochemical Pharmacology   Check publisher's open access policy
ISSN 0006-2952
Publication date 1992-07-07
Sub-type Article (original research)
DOI 10.1016/0006-2952(92)90053-L
Volume 44
Issue 1
Start page 177
End page 179
Total pages 3
Language eng
Subject 3004 Pharmacology
Abstract Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki, value of 42 ± 3 μM, whereas inhibition of TK was complex.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ResearcherID Downloads
Scopus Import - Archived
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 12 Sep 2015, 04:35:46 EST by System User