Effective absorption and utilization of oral formyltetrahydrofolate in man

Nixon, Peter F. and Bertino, Joseph R. (1972) Effective absorption and utilization of oral formyltetrahydrofolate in man. New England Journal of Medicine, 286 4: 175-179. doi:10.1056/NEJM197201272860402

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Author Nixon, Peter F.
Bertino, Joseph R.
Title Effective absorption and utilization of oral formyltetrahydrofolate in man
Journal name New England Journal of Medicine   Check publisher's open access policy
ISSN 0028-4793
1533-4406
Publication date 1972-01-01
Sub-type Article (original research)
DOI 10.1056/NEJM197201272860402
Open Access Status File (Publisher version)
Volume 286
Issue 4
Start page 175
End page 179
Total pages 5
Place of publication Waltham, MA, United States
Publisher Massachusetts Medical Society
Language eng
Formatted abstract
Reversal of the effects of antifolates requires effective expansion of the body pool of reduced folate coenzymes. In the past, this has required parenteral use of 5-formyltetrahydrofolate. By use of Radio-labeled 5-formyltetrahydrofolate, we showed that its oral administration also expands the body reduced folate pool. After oral administration of 5-formyl-14C-tetrahydrofolate-3H to fasting subjects, the labels appeared in the serum, peaking at 60 minutes. Chromatographic analysis showed that the labeled serum folate was principally the naturally occurring 5-methyltetrahydrofolate-3H. Close to 90 per cent of orally administered 5-formyltetrahydrofolate appeared to be absorbed. The most constant labeled urinary folate was found to be 10-formyltetrahydrofolate or 5, 10-methenyltetrahydrofolate. Renal excretion of labeled 5-formyltetrahydrofolate occurred at undetectable serum levels whereas renal excretion of labeled 5-methyltetrahydrofolate was proportional to its serum concentration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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