Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol

Zimitat, C, Kril, J, Harper, CG and Nixon, PF (1990) Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol. Alcohol, 7 6: 493-501. doi:10.1016/0741-8329(90)90038-E


Author Zimitat, C
Kril, J
Harper, CG
Nixon, PF
Title Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol
Journal name Alcohol   Check publisher's open access policy
ISSN 0741-8329
Publication date 1990-01-01
Year available 1990
Sub-type Article (original research)
DOI 10.1016/0741-8329(90)90038-E
Open Access Status Not yet assessed
Volume 7
Issue 6
Start page 493
End page 501
Total pages 9
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 1303 Specialist Studies in Education
2700 Medicine
2800 Neuroscience
2802 Behavioral Neuroscience
3005 Toxicology
3306 Health (social science)
Abstract The clinical and neuropathological consequences of either ethanol consumption or thiamin deficiency or both were examined in Wistar rats aged nine weeks divided into five groups and fed one of the following diets: a thiamin-replete (control) diet (A); a thiamin-fortified diet with water (B) or 15% ethanol (C); or a thiamin-deficient diet with water (D) or 15% ethanol (E). Rats fed diets A, B or C for 35 weeks showed no clinical signs of neurological disease at any stage and no significant brain pathology when harvested. Rats fed diets D and E progressed through a common sequence of clinical signs of neurological disease typical of acute thiamin deficiency, viz loss of coat condition, ataxia, opisthotonus and ultimately death within 10-23 weeks. The onset and progression of these stages of neurological disease were significantly earlier and faster (p<0.001 for proportion of opisthotonic and ataxic animals at weeks 10 and 15) in the thiamin-deficient rats that received ethanol than in those that did not. At death, the brain pathology in these two groups was limited and similar.
Keyword Ethanol
Rat model
Thiamin deficiency
Wernicke's Encephalopathy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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